Neoplasia — Flashcards

Flashcard 211: What variant of rhabdomyosarcoma is seen in adults?_____

Answer: Pleomorphic

Flashcard 212: In Wilms tumour, metastasis to the _____ occurs early

Answer: lungs

Flashcard 213: Hepatoblastoma has been associated with the _____ syndrome

Answer: familial adenomatous polyposis (FAP) (cancer)

Flashcard 214: The biologic behaviour of chondrosarcoma directly correlates with the _____ of tumor

Answer: grade

Flashcard 215: WHO classification of Nasopharyngeal Carcinoma (NPC): Type III is _____ carcinoma

Answer: Undifferentiated (Lymphoepithelioma)

Extra: WHO Classification of Nasopharyngeal Carcinoma (NPC): - Type I: Keratinizing Squamous Cell Carcinoma (SCC) - Type II: Non-keratinizing SCC - Type III: Undifferentiated carcinoma (most common type, strongly associated with EBV) Note: Basaloid SCC is a rare variant recognized in newer WHO classifications but is distinct from the traditional Type III (undifferentiated) category.

Flashcard 216: _____ is associated with carcinoma of the Ampulla of Vater of the CBD

Answer: Familial adenomatous polyposis (Cancer syndrome)

Flashcard 217: Angiosarcoma and hemangiopericytoma are _____ grade neoplasms

Answer: malignant

Flashcard 218: Two-thirds of fibroadenomas harbor driver mutations in _____ gene

Answer: MED12

Flashcard 219: Tumors confined to the muscle layer, no lymph node invasion are classified as _____ according to Modified Duke's classification

Answer: B1

Extra: Modified Duke's (Astler-Coller) classification for Colorectal Cancer: - **A**: Limited to mucosa - **B1**: Extending **into** muscularis propria (nodes negative) - **B2**: Extending **through** muscularis propria into the serosa/subserosa (nodes negative) - **C1**: Extending into muscularis propria (nodes positive) - **C2**: Extending through muscularis propria (nodes positive) - **D**: Distant metastasis Since the tumor is "confined to" the muscle layer, it is classified as B1.

Flashcard 220: Pure fetal histology in hepatoblastoma is associated with a _____ prognosis

Answer: good