Neoplasia — Flashcards

_____ is a malignant germ cell tumor composed of mononuclear cytotrophoblasts and multinuclear syncytiotrophoblasts, but with absent villi

_____ molecular subtype is a triple-negative breast cancer with low expression of E-cadherin and a poor prognosis.

_____ is a non-invasive breast cancer characterized by dyscohesive cells due to lack of E-cadherin protein

Loss of copies of a tumor suppressor gene (knudson two-hit hypothesis) arise from _____ (inherited) or somatic (sporadic) mutations

ER/PR-_____, HER2-negative breast cancer is the most common subtype in individuals who inherit germline mutations in BRCA1

A follicular lymphoma due to Bcl-2 overexpression results from a _____ translocation.

Small cell carcinoma is characterized histologically by _____ differentiated small cells and is thus very aggressive

_____ is a salivary gland tumor composed of chondromyxoid stroma and epithelium

2-Naphthylamine is a carcinogenic aromatic amine found in _____ associated with Transitional Cell Carcinoma of the Bladder

Wilms tumor is caused by "loss of function" mutations of tumor suppression genes _____ or WT2 on chromosome 11