Neoplasia — Flashcards

Acoustic neuromas are _____ whereas glomus tumors are non-capsulated (capsulated/non-capsulated)

The tumor suppressors encoded by the CDKN2A gene enforce the G1-->S restriction point by:(1) - inhibiting CDK_____/6 (2) - relieving inhibition of P53

The T of TNM staging for renal cell carcinoma represents the tumor _____ and involvement of the renal vein

A characteristic of the transformation from normal cells to dysplastic cells is that there is is an increased _____ to cytoplasmic ratio

Neurofibromatosis type I is associated with mutations in the _____ tumor suppressor gene on chromosome 17

Loss of copies of a tumor suppressor gene (knudson two-hit hypothesis) arise from _____ (inherited) or somatic (sporadic) mutations

_____ is a malignant germ cell tumor composed of mononuclear cytotrophoblasts and multinuclear syncytiotrophoblasts, but with absent villi

One subtype of invasive ductal carcinoma (breast) is _____ carcinoma, which is characterized by large, high-grade malignant cells growing in sheets with lymphocytic infiltrate

Metastasis oncogenes such as _____ and TWIST encode transcription factors whose primary function is to promote epithelial-to-mesenchymal transition (EMT).

Tumor staging is based on _____ (c) or pathological (p) findings