Neoplasia — Flashcards

Patients with a germline Rb mutation will typically develop a _____ Retinoblastoma, with an increased risk of osteosarcoma and pinealoblastoma ("trilateral" retinoblastoma)

Tumors that present with **PSaMMOMA** bodies: - **P**: _____ - **S**: Somatostatinoma - **M**: Meningioma - **M**: Malignant mesothelioma - **O**: Ovarian serous papillary cystadenocarcinoma - **M**: Milk (prolactinoma) - **A**: Adenocarcinoma (Endometrial serous)

The tumor suppressors encoded by the CDKN2A gene enforce the G1-->S restriction point by:(1) - inhibiting CDK_____/6 (2) - relieving inhibition of P53

One subtype of invasive ductal carcinoma (breast) is _____ carcinoma, which is characterized by an erythematous and swollen breast that does not resolve with antibiotics

Invasive lobular carcinoma grows in a _____ pattern due to lack of E-cadherin encoded by gene CDH-1

The T of TNM staging for renal cell carcinoma represents the tumor _____ and involvement of the renal vein

The KIT _____ encodes for the Stem Cell Factor receptor, which when bound leads to cell growth. This is a growth factor receptor found commonly in GI stromal tumor

Prostatic adenocarcinoma often has _____ metastases, which is indicated by lower back pain

Hint: type

Epithelial tumors that grow _____ are known as papillomas when benign and papillary carcinoma when malignant

Some _____ secrete PTH-related peptide (PTH-rp), which is structurally homologous with the PTH secreted by the parathyroid glands