Hematopathology — Flashcards

Flashcard 61: One subtype of AML is _____, which is characterized by t(15;17)

Answer: acute promyelocytic leukemia (APL)

Flashcard 62: _____ are identified on blood smear as large RBCs (size) with a bluish (color) cytoplasm

Answer: Reticulocytes

Flashcard 63: _____ lymphoma is driven by a t(11;14) translocation

Answer: Mantle cell

Flashcard 64: Reed-Sternberg cells of Hodgkin's lymphoma are CD_____+ and CD30+

Answer: 15

Flashcard 65: Aplastic anemia can transform into either _____ leukemia and myelodysplastic syndrome

Answer: acute myeloid

Flashcard 66: B-ALL is usually characterized by lymphoblasts (TdT+) that express CD_____, CD19, and CD20

Answer: 10

Flashcard 67: Anemia of chronic disease is associated with a(n) _____ free erythrocyte protoporphyrin (FEP)

Answer: increased

Flashcard 68: What is the associated tumor that results from 9;22 translocation of the ABL oncogene?_____

Answer: CML

Flashcard 69: _____ leukemia is characterized by a translocation between chromosome 9 and chromosome 22, resulting in the BCR-ABL fusion gene.

Answer: Chronic myeloid

Extra: The translocation is t(9;22)(q34;q11), which creates the **Philadelphia chromosome** (the shortened derivative chromosome 22). This fusion gene encodes a protein with constitutive tyrosine kinase activity.

Flashcard 70: Impaired division of granulocytic precursors in _____ anemia leads to hypersegmented neutrophils

Answer: megaloblastic