Hematopathology — Flashcards

Flashcard 421: _____ anemia is a form of marrow failure in which space-occupying lesions replace normal bone marrow elements

Answer: Myelophthisic

Flashcard 422: _____ syndrome is the transformation of _____ to aggressive lymphoma

Answer: Richter's; chronic lymphocytic leukemia (CLL)

Flashcard 423: Glucose 6 phosphate dehydrogenase (G6PD) deficiency leads to _____ hemolysis

Answer: both extravascular and intravascular

Flashcard 424: _____ syndrome is the transformation of _____ to aggressive lymphoma

Answer: Richter's; chronic lymphocytic leukemia (CLL)

Flashcard 425: G6PD deficiency has _____ red cells.

Answer: Bite cells (degmacytes) and Blister cells

Extra: Oxidative stress in G6PD deficiency leads to the oxidation of hemoglobin into Heinz bodies. As these cells pass through the splenic sinusoids, splenic macrophages 'bite' out the Heinz bodies, resulting in Bite cells (degmacytes). Blister cells are also seen where the hemoglobin has contracted away from the cell membrane.

Flashcard 426: Sickle cells have _____ mechanical fragility and _____ osmotic fragility.

Answer: high; low

Flashcard 427: Tumor cells with multilobulated nuclei ( cloverleaf or flower cells) is characteristic of _____

Answer: Adult T-Cell Leukemia/Lymphoma