Plasma Cell Disorders — Flashcards

Flashcard 1: Plasma cell tumors such as multiple myeloma are positive for CD_____

Answer: 138

Flashcard 2: Hemoglobin >_____ g/dL or Hematocrit >49% in men + bone marrow showing trilineage (or panmyelosis) growth +JAK2 mutation are major criteria for Polycythemia Vera

Answer: 16.5

Flashcard 3: Best immunohistochemical marker for multiple myeloma is _____

Answer: CD138 (Syndecan-1)

Extra: CD138 is the most sensitive and specific marker for identifying plasma cells in bone marrow biopsies. Other markers: - **CD38**: Also highly expressed on plasma cells. - **CD56**: Frequently positive in neoplastic plasma cells (Multiple Myeloma) but negative in reactive plasma cells. - **MUM1**: Expressed in plasma cells and some B-cells. - **Cyclin D1**: Specifically expressed in the subset of Multiple Myeloma with t(11;14) translocation.

Flashcard 4: Multiple myeloma presents with _____ bone lesions and hypercalcemia

Answer: lytic (punched-out)

Flashcard 5: _____ bodies are irregular, dark, blue-purple granules, seen at the periphery of siderocytes, which stain iron positive

Answer: Pappenheimer

Flashcard 6: _____ will show decreased mean fluorescence of RBCs in eosin 5-maleimide (EMA) binding test

Answer: Hereditary spherocytosis

Flashcard 7: _____ is a marker for Waldenström macroglobulinemia

Answer: MYD88

Flashcard 8: Bone marrow in AL amyloidosis shows _____

Answer: bone marrow plasmacytosis

Flashcard 9: Which of the following is a discrete tumor mass arising from lymph nodes? _____

Answer: Lymphoma

Flashcard 10: What form of non-Hodgkin lymphoma is seen in the image below? _____

Answer: Follicular lymphoma