Hematopathology — Flashcards

Flashcard 411: The ratio between fat cells to hematopoietic elements in a normal adult is about _____

Answer: 1:1

Flashcard 412: Mesenteric group of lymph nodes and Waldeyer ring are frequently involved in a _____Hodgkin's lymphoma

Answer: Non-

Flashcard 413: What variant of Hodgkin's lymphoma is associated with maximum necrosis of the lymph nodes?_____

Answer: Lymphocyte depleted

Flashcard 414: Sago spleen is due to deposition of amyloid in follicles of _____ pulp.

Answer: white

Flashcard 415: The best investigation to diagnose marrow aplasia is bone marrow _____

Answer: biopsy

Flashcard 416: What is the investigation of choice for diagnosing myelofibrosis?_____

Answer: Bone marrow biopsy

Flashcard 417: G6PD deficiency has _____ red cells.

Answer: Bite cells (degmacytes) and Blister cells

Extra: Oxidative stress in G6PD deficiency leads to the oxidation of hemoglobin into Heinz bodies. As these cells pass through the splenic sinusoids, splenic macrophages 'bite' out the Heinz bodies, resulting in Bite cells (degmacytes). Blister cells are also seen where the hemoglobin has contracted away from the cell membrane.

Flashcard 418: _____ test detects lysis of RBCs in a mildly acidic pH due to complement fixation.

Answer: Ham

Flashcard 419: Classical immunophenotypic feature of CLL on Flow cytometry is CD 19+, CD20+, CD _____, CD _____

Answer: 23+; 5+

Flashcard 420: Sickle cells have _____ mechanical fragility and _____ osmotic fragility.

Answer: high; low