Hematopathology — Flashcards

Flashcard 411: Pelger Huet syndrome, which is a defect of terminal neutrophil differentiation, occurring as a result of mutations in the _____-receptor gene

Answer: lamin B

Flashcard 412: Marginal zone lymphomas are considered to be of _____ B cell origin

Answer: post-germinal center memory

Flashcard 413: Which blood products have a high chance of bacterial contamination?_____

Answer: Platelets

Flashcard 414: What is the investigation of choice for diagnosing myelofibrosis?_____

Answer: Bone marrow biopsy

Flashcard 415: The best investigation to diagnose marrow aplasia is bone marrow _____

Answer: biopsy

Flashcard 416: _____ anemia is a form of marrow failure in which space-occupying lesions replace normal bone marrow elements

Answer: Myelophthisic

Flashcard 417: _____ syndrome is the transformation of _____ to aggressive lymphoma

Answer: Richter's; chronic lymphocytic leukemia (CLL)

Flashcard 418: Classical immunophenotypic feature of CLL on Flow cytometry is CD 19+, CD20+, CD _____, CD _____

Answer: 23+; 5+

Flashcard 419: G6PD deficiency has _____ red cells.

Answer: Bite cells (degmacytes) and Blister cells

Extra: Oxidative stress in G6PD deficiency leads to the oxidation of hemoglobin into Heinz bodies. As these cells pass through the splenic sinusoids, splenic macrophages 'bite' out the Heinz bodies, resulting in Bite cells (degmacytes). Blister cells are also seen where the hemoglobin has contracted away from the cell membrane.

Flashcard 420: _____ test detects lysis of RBCs in a mildly acidic pH due to complement fixation.

Answer: Ham