Hemolytic Anemias — Flashcards

Flashcard 1: G6PD deficiency has _____ red cells.

Answer: Bite cells (degmacytes) and Blister cells

Extra: Oxidative stress in G6PD deficiency leads to the oxidation of hemoglobin into Heinz bodies. As these cells pass through the splenic sinusoids, splenic macrophages 'bite' out the Heinz bodies, resulting in Bite cells (degmacytes). Blister cells are also seen where the hemoglobin has contracted away from the cell membrane.

Flashcard 2: Which is the only hemolytic anemia caused by an acquired genetic defect?_____

Answer: Paroxysmal nocturnal hemoglobinuria (PNH)

Flashcard 3: Normocytic anemia with _____-vascular hemolysis is associated with decreased serum haptoglobin

Answer: intra

Flashcard 4: Normocytic anemia with _____-vascular hemolysis is associated with enlargement of the spleen (splenomegaly)

Answer: extra

Flashcard 5: Delayed hemolytic transfusion reaction (DHTR) is Ig_____ mediated and caused by antibodies in patients previously sensitized to RBC antigens

Answer: G

Flashcard 6: _____ anemia occurs when RBCs are "sheared" as they cross microthrombi

Answer: Microangiopathic hemolytic

Flashcard 7: In β-thalassemia major, α₄ tetramers result in _____ erythropoiesis and extravascular hemolysis

Answer: ineffective

Flashcard 8: _____ is an autosomal dominant hematological disorder that involves spheroid erythrocytes due to a spectrin or ankyrin defect.

Answer: Hereditary Spherocytosis

Flashcard 9: Which of the following is a discrete tumor mass arising from lymph nodes? _____

Answer: Lymphoma

Flashcard 10: What form of non-Hodgkin lymphoma is seen in the image below? _____

Answer: Follicular lymphoma