Hematopathology — Flashcards

Flashcard 71: _____ lymphoma is driven by a t(14;18) translocation

Answer: Follicular

Flashcard 72: _____ leukemia is characterized by a translocation between chromosome 9 and chromosome 22, resulting in the BCR-ABL fusion gene.

Answer: Chronic myeloid

Extra: The translocation is t(9;22)(q34;q11), which creates the **Philadelphia chromosome** (the shortened derivative chromosome 22). This fusion gene encodes a protein with constitutive tyrosine kinase activity.

Flashcard 73: Inv 16 is associated with a _____ prognosis in patients with acute myeloid leukemia

Answer: good

Flashcard 74: α-thalassemia due to a two gene deletion presents with mild _____ with a(n) increased RBC count

Answer: anemia

Flashcard 75: Reed-Sternberg cells of Hodgkin's lymphoma are CD_____+ and CD30+

Answer: 15

Flashcard 76: von Willebrand disease presents with _____ PT and normal or increased PTT

Answer: normal

Flashcard 77: The antibodies in immune hemolytic anemia are either Ig_____ or IgM

Answer: G

Flashcard 78: Type I _____ deficiency leads to deposition of fibrin on mucous membranes

Answer: plasminogen

Flashcard 79: The most common translocation seen in multiple myeloma is _____.

Answer: t(11;14)

Extra: The most common primary translocation in multiple myeloma is **t(11;14)**, which involves the **cyclin D1** gene on chromosome 11 and the **IGH** locus on chromosome 14. Other common translocations include t(4;14) and t(14;16).

Flashcard 80: What is the associated tumor that results from 9;22 translocation of the ABL oncogene?_____

Answer: CML