Hematopathology — Flashcards

Flashcard 71: Anemia of chronic disease is associated with a(n) _____ free erythrocyte protoporphyrin (FEP)

Answer: increased

Flashcard 72: _____ lymphoma is driven by a t(14;18) translocation

Answer: Follicular

Flashcard 73: _____ leukemia is characterized by a translocation between chromosome 9 and chromosome 22, resulting in the BCR-ABL fusion gene.

Answer: Chronic myeloid

Extra: The translocation is t(9;22)(q34;q11), which creates the **Philadelphia chromosome** (the shortened derivative chromosome 22). This fusion gene encodes a protein with constitutive tyrosine kinase activity.

Flashcard 74: α-thalassemia due to a two gene deletion presents with mild _____ with a(n) increased RBC count

Answer: anemia

Flashcard 75: B-ALL is usually characterized by lymphoblasts (TdT+) that express CD_____, CD19, and CD20

Answer: 10

Flashcard 76: The antibodies in immune hemolytic anemia are either Ig_____ or IgM

Answer: G

Flashcard 77: The _____ form of Burkitt lymphoma typically involves the pelvis or abdomen

Answer: sporadic

Flashcard 78: The most common translocation seen in multiple myeloma is _____.

Answer: t(11;14)

Extra: The most common primary translocation in multiple myeloma is **t(11;14)**, which involves the **cyclin D1** gene on chromosome 11 and the **IGH** locus on chromosome 14. Other common translocations include t(4;14) and t(14;16).

Flashcard 79: The M spike seen in _____ is most commonly due to monoclonal IgG (55%) or IgA (25%)

Answer: multiple myeloma

Flashcard 80: Normocytic anemia with _____-vascular hemolysis is associated with decreased serum haptoglobin

Answer: intra