Hematopathology — Flashcards

Flashcard 61: RBCs stored in _____ can be kept until 42 days

Answer: additive solutions

Flashcard 62: Aplastic anemia can transform into either _____ leukemia and myelodysplastic syndrome

Answer: acute myeloid

Flashcard 63: Reed-Sternberg cells of Hodgkin's lymphoma are CD_____+ and CD30+

Answer: 15

Flashcard 64: _____ lymphoma is driven by a t(11;14) translocation

Answer: Mantle cell

Flashcard 65: Anemia of chronic disease is associated with a(n) _____ free erythrocyte protoporphyrin (FEP)

Answer: increased

Flashcard 66: _____ leukemia is characterized by a translocation between chromosome 9 and chromosome 22, resulting in the BCR-ABL fusion gene.

Answer: Chronic myeloid

Extra: The translocation is t(9;22)(q34;q11), which creates the **Philadelphia chromosome** (the shortened derivative chromosome 22). This fusion gene encodes a protein with constitutive tyrosine kinase activity.

Flashcard 67: B-ALL is usually characterized by lymphoblasts (TdT+) that express CD_____, CD19, and CD20

Answer: 10

Flashcard 68: Platelets can be stored between _____C to 24C with a shelf life of 5 days.

Answer: 20

Flashcard 69: Normocytic anemia with _____-vascular hemolysis is associated with decreased serum haptoglobin

Answer: intra

Flashcard 70: What is the associated tumor that results from 9;22 translocation of the ABL oncogene?_____

Answer: CML