Hematopathology — Flashcards

Flashcard 271: Characteristic leukocyte appearance in Pelger-Huet syndrome is with _____-shaped bilobed nuclei

Answer: dumbbell

Flashcard 272: What is the most common subtype of acute lymphoblastic leukemia (ALL)?_____

Answer: Pre-B ALL

Flashcard 273: _____ is the most common non-Hodgkin's lymphoma in children under the age of 15 years.

Answer: Burkitt lymphoma

Flashcard 274: MALTomas are _____ for CD43, which is a T-cell marker

Answer: positive

Flashcard 275: alpha-heavy chain disease is known as _____ disease

Answer: Seligmann's

Flashcard 276: What is the etiological agent for lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia?_____

Answer: Hepatitis C virus

Flashcard 277: MALTomas are _____ for CD10 (CALLA)

Answer: negative

Flashcard 278: Which thrombin-like enzyme is used to differentiate the effect of heparin from afibrinogenemia?

Answer: Reptilase

Extra: Reptilase (from *Bothrops atrox* venom) is a thrombin-like enzyme that converts fibrinogen to fibrin but is **not** inhibited by the heparin-antithrombin III complex. - **Heparin presence:** Prolonged Thrombin Time (TT), Normal Reptilase Time (RT). - **Afibrinogenemia/Dysfibrinogenemia:** Both Thrombin Time and Reptilase Time are prolonged.

Flashcard 279: What is the most common primary malignancy of bone of hematological origin?_____

Answer: Multiple myeloma

Flashcard 280: Pawn ball megakaryocytes or cells with multiple separate nuclei are seen in _____

Answer: myelodysplastic syndrome