Hematopathology — Flashcards

Flashcard 271: What AML subtype is associated with Erythemic myelosis and Di Guglielmo disease?_____

Answer: AML M6 (erythroid)

Flashcard 272: Characteristic leukocyte appearance in Pelger-Huet syndrome is with _____-shaped bilobed nuclei

Answer: dumbbell

Flashcard 273: What is the most common subtype of acute lymphoblastic leukemia (ALL)?_____

Answer: Pre-B ALL

Flashcard 274: Pawn ball megakaryocytes or cells with multiple separate nuclei are seen in _____

Answer: myelodysplastic syndrome

Flashcard 275: _____ positive giant inclusions seen in leukocytes is the first line diagnostic test for Chediak-Higashi syndrome.

Answer: Peroxidase

Flashcard 276: MALTomas are _____ for CD10 (CALLA)

Answer: negative

Flashcard 277: _____ cells have horseshoe-shaped nuclei and voluminous cytoplasm, seen in anaplastic large cell lymphoma

Answer: Hallmark

Flashcard 278: What is the most common primary malignancy of bone of hematological origin?_____

Answer: Multiple myeloma

Flashcard 279: MALTomas are _____ for CD43, which is a T-cell marker

Answer: positive

Flashcard 280: Best immunohistochemical marker for multiple myeloma is _____

Answer: CD138 (Syndecan-1)

Extra: CD138 is the most sensitive and specific marker for identifying plasma cells in bone marrow biopsies. Other markers: - **CD38**: Also highly expressed on plasma cells. - **CD56**: Frequently positive in neoplastic plasma cells (Multiple Myeloma) but negative in reactive plasma cells. - **MUM1**: Expressed in plasma cells and some B-cells. - **Cyclin D1**: Specifically expressed in the subset of Multiple Myeloma with t(11;14) translocation.