Hematopathology — Flashcards

Flashcard 281: MALTomas are _____ for CD43, which is a T-cell marker

Answer: positive

Flashcard 282: Cells in acute myeloid leukemia are _____ for CD33

Answer: positive

Flashcard 283: Histopathological finding of follicular hyperplasia (germinal centers) with a vascular core point towards the diagnosis of _____

Answer: Castleman's disease

Flashcard 284: _____ cells have horseshoe-shaped nuclei and voluminous cytoplasm, seen in anaplastic large cell lymphoma

Answer: Hallmark

Flashcard 285: _____ positive giant inclusions seen in leukocytes is the first line diagnostic test for Chediak-Higashi syndrome.

Answer: Peroxidase

Flashcard 286: Age <1 or >10 years indicates _____ prognosis in acute lymphocytic leukemia (ALL).

Answer: poor

Flashcard 287: What is the maximum threshold for absolute basophilia in the diagnosis of atypical chronic myeloid leukemia (aCML)?

Answer: < 2% of total leukocytes

Extra: Atypical CML (BCR-ABL1 negative) is a myelodysplastic/myeloproliferative neoplasm. Diagnostic criteria include: 1. Leukocytosis (WBC ≥ 13 x 10⁹/L) 2. Neutrophil precursors (promyelocytes, myelocytes, metamyelocytes) ≥ 10% of WBC 3. Minimal absolute basophilia (< 2% of WBC) 4. Minimal monocytosis (< 10% of WBC) 5. Marked dysgranulopoiesis 6. Absence of BCR-ABL1 fusion or other specific rearrangements (PDGFRA, PDGFRB, FGFR1, PCM1-JAK2).

Flashcard 288: What is the most common cytogenetic change in children suffering from myelodysplastic syndrome?_____

Answer: Monosomy 7

Flashcard 289: _____ incompatibility is the most common cause of hemolytic disease of newborn and affects the first-born.

Answer: ABO

Flashcard 290: A _____ LAP score is seen in multiple myeloma

Answer: high