Hematopathology — Flashcards

Flashcard 261: Which lymphoma is characterized by involvement of a single axial group of lymph nodes (e.g., cervical, mediastinal, para-aortic) and contiguous spread?

Answer: Hodgkin lymphoma

Extra: In contrast to Hodgkin lymphoma, Non-Hodgkin lymphoma (NHL) frequently involves multiple peripheral nodes and spreads in a non-contiguous fashion.

Flashcard 262: Reed Sternberg cells in nodular sclerosis variant of Hodgkin lymphoma (HL) are negative for CD_____ (leukocyte common antigen)

Answer: 45

Flashcard 263: Chronic lymphocytic leukemia (CLL) contains a large number of monotonous, uniform-looking, mature lymphocytes, which is often described as a _____ appearance.

Answer: "convent-girl"

Flashcard 264: In an extramedullary tumor mass, the presence of **Auer rods** suggests a diagnosis of _____.

Answer: Chloroma (myeloid sarcoma)

Extra: Chloroma (also known as granulocytic sarcoma or myeloid sarcoma) is an extramedullary tumor mass consisting of myeloblasts. **Auer rods** (needle-like azurophilic cytoplasmic inclusions) are characteristically found in these cells, which helps distinguish them from lymphoblasts.

Flashcard 265: _____ lymphoma is a very aggressive tumor, having a very high mitotic index and a ki67 of about 100%.

Answer: Burkitt's

Flashcard 266: _____ is a lipophilic dye that binds irreversibly to an undefined granule component of myeloid cells (granulocytes and precursors, eosinophils and monocytes)

Answer: Sudan Black B (SBB)

Flashcard 267: What AML subtype is associated with inv(16) and t(16;16)?

Answer: AML M4eo (Acute myelomonocytic leukemia with eosinophilia)

Flashcard 268: Characteristic leukocyte appearance in Pelger-Huet syndrome is with _____-shaped bilobed nuclei

Answer: dumbbell

Flashcard 269: What AML subtype is associated with Erythemic myelosis and Di Guglielmo disease?_____

Answer: AML M6 (erythroid)

Flashcard 270: _____ lymphomas may invade epithelial structures to form lymphoepithelial lesions

Answer: Marginal zone