Hematopathology — Flashcards

Flashcard 261: _____ lymphoma is a very aggressive tumor, having a very high mitotic index and a ki67 of about 100%.

Answer: Burkitt's

Flashcard 262: Chronic lymphocytic leukemia (CLL) contains a large number of monotonous, uniform-looking, mature lymphocytes, which is often described as a _____ appearance.

Answer: "convent-girl"

Flashcard 263: Reed Sternberg cells in nodular sclerosis variant of Hodgkin lymphoma (HL) are negative for CD_____ (leukocyte common antigen)

Answer: 45

Flashcard 264: What AML subtype is associated with inv(16) and t(16;16)?

Answer: AML M4eo (Acute myelomonocytic leukemia with eosinophilia)

Flashcard 265: In an extramedullary tumor mass, the presence of **Auer rods** suggests a diagnosis of _____.

Answer: Chloroma (myeloid sarcoma)

Extra: Chloroma (also known as granulocytic sarcoma or myeloid sarcoma) is an extramedullary tumor mass consisting of myeloblasts. **Auer rods** (needle-like azurophilic cytoplasmic inclusions) are characteristically found in these cells, which helps distinguish them from lymphoblasts.

Flashcard 266: _____ is a lipophilic dye that binds irreversibly to an undefined granule component of myeloid cells (granulocytes and precursors, eosinophils and monocytes)

Answer: Sudan Black B (SBB)

Flashcard 267: _____ is the most common non-Hodgkin's lymphoma in children under the age of 15 years.

Answer: Burkitt lymphoma

Flashcard 268: Myeloperoxidase and acid hydrolases are a part of _____ granules of neutrophils.

Answer: primary (azurophilic)

Flashcard 269: A nonparatrabecular pattern of infiltration on bone marrow biopsy points to the diagnosis of _____

Answer: Waldenstrom macroglobulinemia

Flashcard 270: _____ lymphomas may invade epithelial structures to form lymphoepithelial lesions

Answer: Marginal zone