Hematopathology — Flashcards

Flashcard 231: Inherited form of thrombotic thrombocytopenic purpura is also referred to as _____ syndrome

Answer: Upshaw-Schulman

Flashcard 232: Hemophagocytic lymphohistiocytosis is characterized by low or absent _____ cell activity

Answer: NK

Flashcard 233: Quebec platelet syndrome is a disorder involving which platelet granules?

Answer: Alpha (α) granules

Extra: Quebec platelet syndrome (QPS) is an autosomal dominant disorder characterized by high levels of **urokinase plasminogen activator (u-PA)** within alpha-granules. This leads to the intra-platelet degradation of alpha-granule proteins (e.g., Factor V, fibrinogen, VWF) once the platelets are activated.

Flashcard 234: Large granular lymphocytic leukemia will have mutations in the _____ gene

Answer: STAT3

Flashcard 235: _____ is a marker for Waldenström macroglobulinemia

Answer: MYD88

Flashcard 236: Delayed umbilical stump bleeding is characteristic of factor _____ deficiency.

Answer: XIII

Flashcard 237: _____ is an aggressive lymphoid neoplasm that classically occurs in the oral cavity in immunosuppressed patients

Answer: Plasmablastic lymphoma

Flashcard 238: What is the most common bilateral testicular tumors?_____

Answer: Lymphoma

Flashcard 239: What is the inheritence pattern of Bernard-Soulier syndrome?_____

Answer: Autosomal Recessive

Flashcard 240: _____ protein deficiency is responsible for the mushroom cell shape of the RBCs

Answer: Band 3