Hematopathology — Flashcards

Flashcard 241: What is the inheritence pattern of Bernard-Soulier syndrome?_____

Answer: Autosomal Recessive

Flashcard 242: _____ protein deficiency is responsible for the mushroom cell shape of the RBCs

Answer: Band 3

Flashcard 243: Anaplastic large cell lymphoma is a _____-cell lymphoma with large lymphoid cells

Answer: T

Flashcard 244: Delayed umbilical stump bleeding is characteristic of factor _____ deficiency.

Answer: XIII

Flashcard 245: In Small Lymphocytic Lymphoma (SLL), the absolute lymphocyte count is < _____ per mm³.

Answer: 5,000 (If ≥ 5,000, it is classified as CLL)

Extra: Small Lymphocytic Lymphoma (SLL) and Chronic Lymphocytic Leukemia (CLL) are biologically the same disease. The distinction is based on where the bulk of the disease is located and the peripheral blood count: - **SLL:** Lymphadenopathy + Absolute Lymphocyte Count (ALC) < 5,000/mm³ - **CLL:** ALC ≥ 5,000/mm³ (regardless of lymph node involvement)

Flashcard 246: What AML subtype is associated with organ infiltration?_____

Answer: AML M5

Flashcard 247: Lymph node biopsy of CLL will show loose aggregates of small lymphocytes and larger activated lymphocytes, commonly referred to as _____ centres

Answer: proliferation

Flashcard 248: What is the anticoagulant used in black coloured ESR vaccutainer?_____

Answer: Citrate

Flashcard 249: Which form (primary or secondary) myelodysplastic syndrome show high risk of transforming to AML?_____

Answer: Secondary/therapy related

Flashcard 250: Activation of the transcription factor _____ is a common event in classical Hodgkin's lymphoma (HL).

Answer: NF-κB