Hematopathology — Flashcards

Flashcard 241: Anaplastic large cell lymphoma is a _____-cell lymphoma with large lymphoid cells

Answer: T

Flashcard 242: In Small Lymphocytic Lymphoma (SLL), the absolute lymphocyte count is < _____ per mm³.

Answer: 5,000 (If ≥ 5,000, it is classified as CLL)

Extra: Small Lymphocytic Lymphoma (SLL) and Chronic Lymphocytic Leukemia (CLL) are biologically the same disease. The distinction is based on where the bulk of the disease is located and the peripheral blood count: - **SLL:** Lymphadenopathy + Absolute Lymphocyte Count (ALC) < 5,000/mm³ - **CLL:** ALC ≥ 5,000/mm³ (regardless of lymph node involvement)

Flashcard 243: Which subtype of MGUS can progress to Waldenström macroglobulinemia?

Answer: IgM MGUS

Flashcard 244: The test for prothrombin time is done within _____ hours.

Answer: 24

Extra: According to CLSI H21-A5 guidelines and standard textbooks (e.g., Harsh Mohan Pathology), samples for Prothrombin Time (PT) are stable for up to 24 hours at room temperature (25°C). In contrast, Activated Partial Thromboplastin Time (APTT) samples are more labile and should be tested within 4 hours.

Flashcard 245: Lymph node biopsy of CLL will show loose aggregates of small lymphocytes and larger activated lymphocytes, commonly referred to as _____ centres

Answer: proliferation

Flashcard 246: Do patients with juvenile CML have philadelphia chromosome?_____

Answer: No

Flashcard 247: Which form (primary or secondary) myelodysplastic syndrome show high risk of transforming to AML?_____

Answer: Secondary/therapy related

Flashcard 248: Activation of the transcription factor _____ is a common event in classical Hodgkin's lymphoma (HL).

Answer: NF-κB

Flashcard 249: What AML subtype is associated with organ infiltration?_____

Answer: AML M5

Flashcard 250: What is the anticoagulant used in black coloured ESR vaccutainer?_____

Answer: Citrate