Hematopathology — Flashcards

Flashcard 221: Coomb's _____ hemolytic anemia maybe seen in Wilson's disease due to large amounts of copper released from damaged hepatocytes

Answer: negative

Flashcard 222: _____ is a unique subtype of MGUS in which there is no immunoglobulin heavy-chain component

Answer: LC-MGUS

Flashcard 223: Cryoprecipitate is stored at a temperature of _____ °C

Answer: -18°C or colder (commonly -30°C)

Extra: Cryoprecipitate is prepared by thawing Fresh Frozen Plasma (FFP) at 4°C and collecting the precipitate. Storage: - Frozen: -18°C or colder for up to 1 year. - Thawed: 20–24°C (room temperature); must be transfused within 6 hours (or 4 hours if pooled in an open system). Do NOT refrigerate after thawing as it causes reprecipitation of clotting factors. Contents: Fibrinogen, Factor VIII, Factor XIII, von Willebrand factor (vWF), and Fibronectin.

Flashcard 224: Hermansky-Pudlak syndrome is a disorder involving platelet _____ granules

Answer: Dense (delta) granules

Flashcard 225: What is the confirmatory test for Factor XIII deficiency?_____

Answer: Urea lysis test

Flashcard 226: Quebec platelet syndrome is a disorder involving which platelet granules?

Answer: Alpha (α) granules

Extra: Quebec platelet syndrome (QPS) is an autosomal dominant disorder characterized by high levels of **urokinase plasminogen activator (u-PA)** within alpha-granules. This leads to the intra-platelet degradation of alpha-granule proteins (e.g., Factor V, fibrinogen, VWF) once the platelets are activated.

Flashcard 227: Hemophagocytic lymphohistiocytosis is characterized by low or absent _____ cell activity

Answer: NK

Flashcard 228: What is the most common tumor arising due to ionizing radiation (medical imaging)?_____

Answer: Myeloid leukemia

Flashcard 229: If the Mentzer index is _____, the patient likely has iron deficiency anemia.

Answer: > 13

Flashcard 230: Deficiency of factor _____ is also referred to as Stuart-prower disease

Answer: X