Hematopathology — Flashcards

Flashcard 221: _____ is a unique subtype of MGUS in which there is no immunoglobulin heavy-chain component

Answer: LC-MGUS

Flashcard 222: Hermansky-Pudlak syndrome is a disorder involving platelet _____ granules

Answer: Dense (delta) granules

Flashcard 223: Biallelic mutation in CEBPA suggests a _____ prognosis for AML

Answer: good

Flashcard 224: What is the most common subtype of MGUS?_____

Answer: Non-IgM MGUS

Flashcard 225: Coomb's _____ hemolytic anemia maybe seen in Wilson's disease due to large amounts of copper released from damaged hepatocytes

Answer: negative

Flashcard 226: Which AML subtype is also known as Schilling type?_____

Answer: AML M5 (monocytic or monoblastic)

Flashcard 227: Quebec platelet syndrome is a disorder involving which platelet granules?

Answer: Alpha (α) granules

Extra: Quebec platelet syndrome (QPS) is an autosomal dominant disorder characterized by high levels of **urokinase plasminogen activator (u-PA)** within alpha-granules. This leads to the intra-platelet degradation of alpha-granule proteins (e.g., Factor V, fibrinogen, VWF) once the platelets are activated.

Flashcard 228: Inherited form of thrombotic thrombocytopenic purpura is also referred to as _____ syndrome

Answer: Upshaw-Schulman

Flashcard 229: If the Mentzer index is _____, the patient likely has iron deficiency anemia.

Answer: > 13

Flashcard 230: The transfusion of packed RBCs (PRBC) should be completed within a maximum period of _____ hours after the removal from the blood fridge.

Answer: 4