Hematopathology — Flashcards

Flashcard 211: Marginal zone lymphoma (MALT type) can harbour _____, t(1;14), or t(14;18) translocations that render their growth and survival antigen-independent.

Answer: t(11;18)

Extra: These translocations lead to constitutive activation of the **NF-κB** pathway, bypassing the need for chronic antigen stimulation (e.g., *H. pylori*): - **t(11;18)(q21;q21)**: *BIRC3-MALT1* (formerly *API2-MALT1*) — most common. - **t(1;14)(p22;q32)**: *BCL10-IGH*. - **t(14;18)(q32;q21)**: *IGH-MALT1* (Distinct from the t(14;18) in follicular lymphoma which involves *BCL2*).

Flashcard 212: The _____ screen causes cells with any amount of HbS to sickle

Answer: metabisulfite

Flashcard 213: Which white blood cells can be elevated in patients of polycythemia vera?_____

Answer: Basophils and eosinophils

Flashcard 214: In atypical chronic myeloid leukemia (aCML), monocytes typically constitute what percentage of the white blood cell count?

Answer: < 10%

Extra: Atypical chronic myeloid leukemia (BCR-ABL1 negative) is a myelodysplastic/myeloproliferative neoplasm (MDS/MPN) characterized by leukocytosis and prominent granulocytic dysplasia. One of the diagnostic criteria to distinguish aCML from CMML is that monocytes must constitute < 10% of the total white blood cell count.

Flashcard 215: DCIP test is a test-tube turbidity test used for the screening of hemoglobin _____

Answer: E

Flashcard 216: Hermansky-Pudlak syndrome is a disorder involving platelet _____ granules

Answer: Dense (delta) granules

Flashcard 217: What is the most common subtype of MGUS?_____

Answer: Non-IgM MGUS

Flashcard 218: Most efficient method for performing leukoreduction is the use of specific _____ filters

Answer: 3rd generation (leukocyte-reduction)

Flashcard 219: Coomb's _____ hemolytic anemia maybe seen in Wilson's disease due to large amounts of copper released from damaged hepatocytes

Answer: negative

Flashcard 220: _____ is a unique subtype of MGUS in which there is no immunoglobulin heavy-chain component

Answer: LC-MGUS