Signal Transduction — Flashcards

_____ stimulates fibroblast growth for collagen synthesis

Protein kinase G activates the enzyme _____, which dephosphorylates myosin light chain causing smooth muscle relaxation

Glucagon, cortisol, and epinephrine induce _____ leading to phosphorylation of serine / threonine residues of the insulin receptor and IRS-1

p53 induces apoptosis by activating _____ and BAK, which dimerize and form a pore in the outer mitochondrial membrane

NF-kB activation pathway: Ubiquitination of IkB results in destruction of _____ and release of the NF-kB transcription factor

Inhibition of Gi via the pertussis toxin results in _____ levels of cAMP

Once the mitochondrial membrane has been made permeable, _____ can leak out and activate initiator caspases

In the phospholipase C mechanism of cellular signaling, _____ and diacylglycerol (DAG) activate protein kinase C, which phosphorylates specific proteins to produce physiologic actions

Gi proteins _____ the cAMP signaling cascade

Gq proteins _____ the IP3-DAG signaling cascade