Inositol Phosphate Pathway — Flashcards

Flashcard 1: _____ is responsible for signal transmission as well as the generation of impulses in the retina

Answer: Phosphatidylinositol (PI)::Phospholipid

Flashcard 2: In the adenylyl cyclase mechanism of cellular signaling, the second messenger _____ activates protein kinase A, which then phosphorylates specific proteins to produce physiologic actions

Answer: cAMP

Flashcard 3: In the phospholipase C mechanism of cellular signaling, the _____ generated from PIP2 causes release of Ca2+ from intracellular stores in the endoplasmic or sarcoplasmic reticulum

Answer: IP3

Flashcard 4: In the phospholipase C mechanism of cellular signaling, _____ and diacylglycerol (DAG) activate protein kinase C, which phosphorylates specific proteins to produce physiologic actions

Answer: Ca2+

Flashcard 5: Activation of a **GPCR** involves the exchange of _____ for _____ on the Gα subunit, leading to its dissociation from the Gβγ complex.

Answer: GDP

Extra: The Gα subunit possesses intrinsic GTPase activity, which hydrolyzes GTP back to GDP to terminate the signal. The GPCR itself acts as a Guanine nucleotide Exchange Factor (GEF) upon ligand binding.

Flashcard 6: Cyclin _____ and Cyclin E-CDK2 drive cells from G1 to S phase

Answer: D-CDK4/CDK6

Flashcard 7: Binding of atrial natriuretic peptide to its receptor guanylyl cyclase causes conversion of _____ to cGMP

Answer: GTP

Flashcard 8: _____ is the only known member of the CX3C chemokine group.

Answer: Fractalkine

Flashcard 9: _____ and Cyclin A-CDK1 are active in S phase.

Answer: Cyclin A-CDK2

Flashcard 10: Growth factor binding to receptor results in Ras replacing _____ with GTP

Answer: GDP