Signal Transduction — Flashcards

_____ protein inhibits the extrinsic pathway of apoptosis, which is mediated by the death receptor.

In the adenylyl cyclase mechanism of cellular signaling, the second messenger _____ activates protein kinase A, which then phosphorylates specific proteins to produce physiologic actions

_____ causes decreased degradation of the extracellular matrix due to the inhibition of metalloproteinases.

Hint: cytokine

Once bound (activated), the glucocorticoid receptor enters the _____ and binds to glucocorticoid response elements to regulate gene transcription

When light strikes the retina, _____ retinal is converted to all-trans retinal

_____ receptors bind glycoproteins and contain three domains; an extracellular domain for ligand binding, a transmembrane domain, and an intracellular domain coupled with heterotrimeric G proteins

Increased levels of cGMP cause _____ dephosphorylation, preventing its interaction with actin

Dense granules of platelets contain _____ and ADP

In the phospholipase C mechanism of cellular signaling, the _____ generated from PIP2 causes release of Ca2+ from intracellular stores in the endoplasmic or sarcoplasmic reticulum

NF-kB activation pathway: IkB kinase phosphorylates the _____ complex, leading to ubiquitination of IkB