MAP Kinase Cascades — Flashcards

Flashcard 1: Caspase _____ and 10 (Extrinsic pathway) and Caspase _____ (Intrinsic pathway) are initiators of Apoptosis

Answer: 8; 9

Flashcard 2: _____ protein inhibits the extrinsic pathway of apoptosis, which is mediated by the death receptor.

Answer: FLIP

Flashcard 3: Which caspase is activated in intrinsic pathway of apoptosis (in response to ER stress)?_____

Answer: Caspase-12

Flashcard 4: NF-kB activation pathway: IkB kinase phosphorylates the _____ complex, leading to ubiquitination of IkB

Answer: IkB-NF-kB

Flashcard 5: In the phospholipase C mechanism of cellular signaling, _____ and diacylglycerol (DAG) activate protein kinase C, which phosphorylates specific proteins to produce physiologic actions

Answer: Ca2+

Flashcard 6: A common Ras pathway mutation results in mutations of GAP, resulting in a lack of _____ to GDP inactivation

Answer: GTP

Flashcard 7: Growth factor binding to receptor results in Ras replacing _____ with GTP

Answer: GDP

Flashcard 8: Activation of a **GPCR** involves the exchange of _____ for _____ on the Gα subunit, leading to its dissociation from the Gβγ complex.

Answer: GDP

Extra: The Gα subunit possesses intrinsic GTPase activity, which hydrolyzes GTP back to GDP to terminate the signal. The GPCR itself acts as a Guanine nucleotide Exchange Factor (GEF) upon ligand binding.

Flashcard 9: _____ is the only known member of the CX3C chemokine group.

Answer: Fractalkine

Flashcard 10: Cyclin _____ and Cyclin E-CDK2 drive cells from G1 to S phase

Answer: D-CDK4/CDK6