Calcium as Second Messenger — Flashcards

Flashcard 1: _____ protein inhibits the extrinsic pathway of apoptosis, which is mediated by the death receptor.

Answer: FLIP

Flashcard 2: Once nitric oxide diffuses into muscle cells, it activates soluble (cytosolic) guanylyl cyclase, which converts _____ to cGMP

Answer: GTP

Flashcard 3: _____ exocytosis:Involves the proteins from golgi apparatus initially entering the secretory granules, where the processing of prohormones to mature hormones occurs before exocytosis; and is a Ca2+ dependent process

Answer: Regulated/ Non constitutive

Flashcard 4: PTCH1 is a membrane receptor and a _____ regulator of the Hedgehog signaling pathway.

Answer: negative

Flashcard 5: In the phospholipase C mechanism of cellular signaling, the _____ complex activates phospholipase C, which then catalyzes the liberation of DAG and IP3 from PIP2

Answer: q-GTP

Flashcard 6: Activation of a **GPCR** involves the exchange of _____ for _____ on the Gα subunit, leading to its dissociation from the Gβγ complex.

Answer: GDP

Extra: The Gα subunit possesses intrinsic GTPase activity, which hydrolyzes GTP back to GDP to terminate the signal. The GPCR itself acts as a Guanine nucleotide Exchange Factor (GEF) upon ligand binding.

Flashcard 7: _____ and Cyclin A-CDK1 are active in S phase.

Answer: Cyclin A-CDK2

Flashcard 8: _____ is the only known member of the CX3C chemokine group.

Answer: Fractalkine

Flashcard 9: Cyclin _____ and Cyclin E-CDK2 drive cells from G1 to S phase

Answer: D-CDK4/CDK6

Flashcard 10: Binding of atrial natriuretic peptide to its receptor guanylyl cyclase causes conversion of _____ to cGMP

Answer: GTP