Nucleic Acid Biochemistry — Flashcards

_____ inhibits ribonucleotide reductase, which normally catalyzes conversion of UDP to dUDP (pyrimidine synthesis)

Adenosine is converted to _____ via the enzyme adenosine deaminase (purine salvage)

_____ are small, noncoding RNA molecules that post-transcriptionally regulate protein expression. The 3' UTR of target mRNAs contains sequences determining their specificity.

NRTIs inhibit phosphodiester bond formation in a _____ to 3' direction

_____ of cytosine makes uracil

Pyrimidine synthesis begins with _____, CO2, and 2 ATP

A _____ mutation occurs when there is a deletion or insertion of a number of nucleotides not divisible by 3, resulting in misreading of all nucleotides downstream.

dUMP is converted to _____ via the enzyme thymidylate synthase (with methylene THF as a cofactor)

A _____ is negatively charged DNA wrapped around the outside of positively charged proteins called histones

Carbamoyl phosphate synthetase II is activated by _____ and PRPP