Pyrimidine Metabolism and Disorders — Flashcards

_____ inhibits ribonucleotide reductase, which normally catalyzes conversion of UDP to dUDP (pyrimidine synthesis)

In the first step of pyrimidine synthesis, glutamine and CO2 are combined to form _____ via the enzyme carbamoyl phosphate synthetase II (requires 2 ATP)

The only mitochondrial step in pyrimidine synthesis is catalyzed by the enzyme _____

Pyrimidine synthesis begins with _____, CO2, and 2 ATP

Xanthine is converted to _____ by xanthine oxidase

One co-transcriptional modification is the addition of a _____ at the 5' end

Hypoxanthine is converted to _____ via xanthine oxidase

microRNA often leads to the _____ of target mRNA, thus causing decreased translation into protein

Guanosine is converted to _____ via the enzyme purine nucleoside phosphorylase (purine salvage)

Inosine is converted to _____ via the enzyme purine nucleoside phosphorylase (purine salvage)