NEET-PG 2015 Practice Questions

Q: Embryo gets implanted at what stage of development?

Blastocyst. Blastocyst - Implantation into the uterine wall occurs when the embryo has developed into a blastocyst, typically around day 6 post-fertilization [1]. - The blastocyst consists of an inner cell mass (which forms the embryo) and an outer layer called the trophoblast (which contributes to the placenta) [1]. Two cell stage - This stage occurs very early in development, usually within the first 24-30 hours after fertilization [1]. - At this point, the embryo is still in the fallopian tube and has not yet reached the uterus for implantation [1]. Four cell stage - The four-cell stage is also an early cleavage stage, occurring around 2 days post-fertilization [1]. - Like the two-cell stage, the embryo is still in transport through the fallopian tube and is not ready for implantation [1]. Morula - The morula is a solid ball of cells formed by cleavage, typically around day 3-4 post-fertilization [1]. - While it has moved closer to the uterus, it has not yet formed the distinct inner cell mass and trophoblast necessary for successful implantation [1].

Q: What is the most common type of conjoint twin?

Thoracopagus. ***Thoracopagus*** - This type of conjoint twin, fused at the **thorax** and often sharing a heart and liver, is the **most common** variety, accounting for approximately **40%** of all cases. - The shared organs and complex anatomy often pose significant challenges for separation and survival. *Omphalopagus* - These twins are joined at the **abdomen** and typically share a liver, gastrointestinal tract, or other abdominal organs. - This is the second most common type, representing approximately **30-35%** of conjoint twins. *Craniopagus* - This rare form involves fusion at the **head**, often sharing parts of the skull, dura mater, or even brain tissue. - Due to the intricate neurological connections, craniopagus twins present exceptionally complex medical and ethical challenges, accounting for only **2-6%** of cases. *Rachipagus* - These twins are fused dorsally along the **spine** and typically share portions of the vertebral column and spinal cord. - This is an extremely rare type of conjoint twinning, representing less than **2%** of cases.

Q: Uterine height is greater than gestational age of the patient in a case of all except -

IUGR. ***IUGR*** - In **Intrauterine Growth Restriction (IUGR)**, the fetus is smaller than expected for gestational age, leading to a **fundal height** that measures less than the actual gestational age. - This condition is characterized by a **restricted growth rate** of the fetus, causing the uterine size to be disproportionately small. *Fibroid uterus* - The presence of **uterine fibroids** (leiomyomas) can increase the overall size of the uterus beyond what would be expected for a given gestational age. - These benign tumors add bulk to the uterine wall, leading to a **larger-than-expected uterine height**. *Wrong dates* - Incorrect estimation of the **Last Menstrual Period (LMP)** or date of conception can lead to a miscalculation of gestational age. - If the gestational age is **underestimated**, the actual uterine height will appear greater than the calculated gestational age. *Polyhydramnios* - **Polyhydramnios** is a condition characterized by an **excessive accumulation of amniotic fluid**, which distends the uterus. - Increased amniotic fluid volume leads to a significantly **larger uterine size** and a fundal height greater than the gestational age.

Q: Following delivery, a tear involving the perineum and external anal sphincter with intact mucosa is classified as which grade?

Third degree. ***Third degree*** - A third-degree perineal tear involves the **perineum** and the **external anal sphincter (EAS)**, either partially or completely, while the **anal mucosa remains intact**. - This classification is crucial for determining the necessary repair technique and predicting potential long-term complications related to **anal incontinence**. *First degree* - A first-degree tear involves only the **skin** of the perineum and the **vaginal mucosa**, without involving the underlying muscle. - These tears are typically superficial and may not even require suturing. *Second degree* - A second-degree tear involves the **perineal muscles** but does not extend to the anal sphincter. - It includes the vaginal mucosa, perineal skin, and muscles but spares the **external anal sphincter**. *Fourth degree* - A fourth-degree tear is the most severe, involving the **perineum**, **external anal sphincter**, and extending through the **anal mucosa**, exposing the rectal lumen. - These tears carry the highest risk of **fecal incontinence** and require meticulous surgical repair.

Q: Which of the following is NOT a cause of oligohydramnios?

Chorioangioma. ***Chorioangioma*** - A **chorioangioma** is a benign placental tumor that causes **polyhydramnios** (excess amniotic fluid), which is the **opposite** of oligohydramnios. - Large chorioangiomas lead to increased transudation from the tumor's vascular channels, fetal anemia, and high-output cardiac failure, resulting in increased fetal urine production. - This is clearly **NOT a cause** of oligohydramnios, making it the correct answer. *IUGR* - **Intrauterine growth restriction (IUGR)**, particularly with placental insufficiency, is a common cause of **oligohydramnios**. - Reduced placental perfusion leads to decreased **fetal renal blood flow** and diminished urine production. - Since fetal urine is the main source of amniotic fluid after 16 weeks, reduced output causes oligohydramnios. *Renal agenesis* - **Bilateral renal agenesis** (Potter syndrome) is a classic and severe cause of **oligohydramnios/anhydramnios**. - Complete absence of kidneys means **no fetal urine production**, eliminating the primary source of amniotic fluid in the second and third trimesters. - Results in severe oligohydramnios with associated pulmonary hypoplasia and Potter facies. *Amnion nodosum* - **Amnion nodosum** refers to small, grayish-yellow nodules on the fetal surface of the amnion, composed of aggregated fetal squamous epithelial cells and vernix. - These nodules are a **pathological finding** that occurs as a **consequence** of chronic oligohydramnios, not a cause. - They form due to prolonged contact between the fetal skin and amnion when amniotic fluid is severely reduced. - While technically "not a cause," it is strongly **associated with** oligohydramnios, whereas chorioangioma causes the opposite condition entirely.

Q: Which of the following statements about chorionic villus sampling is false?

Is performed only in second trimester of pregnancy. ***Is performed only in second trimester of pregnancy*** - This statement is false because **chorionic villus sampling (CVS)** is typically performed earlier in pregnancy, specifically during the **first trimester**, usually between 10 and 13 weeks of gestation. - Performing CVS only in the second trimester would negate one of its main advantages: providing earlier genetic diagnostic information than **amniocentesis**. *Is used for prenatal genetic diagnosis* - **CVS** is a primary method for **prenatal genetic diagnosis**, allowing for the detection of chromosomal abnormalities and genetic disorders. - It involves analyzing fetal cells obtained from the **chorionic villi**. *Villi are collected from chorion frondosum* - The sample for **CVS** is indeed collected from the **chorion frondosum**, which is the fetal part of the placenta containing numerous chorionic villi. - These villi are genetically identical to the fetus, making them suitable for **genetic analysis**. *Can cause limb deformities* - There is a recognized, albeit small, risk of **limb reduction defects** associated with CVS, particularly if performed very early in gestation (before 9-10 weeks). - This risk is part of the counseling provided to prospective parents considering the procedure.

Q: A 28-year-old primigravida with 32 weeks of gestation presents with profuse vaginal discharge since yesterday. She was advised USG, which showed a single live intrauterine gestational sac with FL and AC corresponding to the weeks of gestation and AFI as adequate. What is the diagnosis?

Normal vaginal discharge. ***Normal vaginal discharge*** - Profuse vaginal discharge is a common and **physiological occurrence** in pregnancy due to increased estrogen levels and blood flow to the vagina. - The ultrasound findings of **adequate amniotic fluid index (AFI)** rule out rupture of membranes, and no other symptoms of infection are reported. *Preterm Premature Rupture of Membranes (PPROM)* - PPROM would present with a significant reduction in the **amniotic fluid index (AFI)** on ultrasound, which is noted as adequate in this case. - The discharge in PPROM is typically **amniotic fluid**, which is clear and watery, unlike mere profuse vaginal discharge. *Trichomoniasis* - This infection typically causes a **frothy, greenish-yellow discharge** with a foul odor, along with vulvar itching and irritation. - These characteristic symptoms are not mentioned in the patient's presentation. *Candidiasis* - Vaginal candidiasis usually presents with a **thick, white, cottage cheese-like discharge** accompanied by intense itching and burning. - The patient's description of discharge is simply "profuse," without these specific characteristics.

Q: Poor prognostic factor for hydatidiform mole is -

WHO score > 8. ***WHO score > 8*** - A **WHO score > 8** (more specifically, WHO/FIGO score ≥7) indicates **high-risk gestational trophoblastic neoplasia (GTN)**, which is associated with a poor prognosis and requires multi-agent chemotherapy. - The WHO prognostic scoring system incorporates various factors: age, prior pregnancy outcome, antecedent pregnancy type, interval from index pregnancy, pre-treatment hCG level, largest tumor size, site of metastases, and number of metastases. - This is the **strongest poor prognostic indicator** among the options listed. *Prior molar pregnancy* - A **prior molar pregnancy** increases the *risk* of developing another molar pregnancy (recurrence risk ~1-2%), but it is **not a component of the WHO prognostic scoring system** and is not a poor prognostic factor for the outcome of current GTN. - The history affects surveillance requirements but doesn't dictate the difficulty of treating the current episode. *Metastasis to lung* - **Lung metastases** are actually among the **better prognostic sites** for metastatic GTN in the WHO scoring system. - Lung and vaginal metastases score only 1 point, whereas liver and brain metastases (true poor prognostic sites) score 4 points each. - While any metastasis indicates more advanced disease, isolated lung metastases generally have a *good prognosis* with appropriate chemotherapy, with cure rates >90%. *No prior chemotherapy* - The *absence* of **prior chemotherapy** is a **favorable prognostic factor**, not a poor one. - Patients who have *failed* prior chemotherapy or have received ≥2 drugs previously score 2-4 points in the WHO system, indicating worse prognosis. - No prior chemotherapy (scores 0 points) means better treatment response and outcomes.

Q: Which of the following drugs is commonly used in the treatment of endometriosis?

Combined oral contraceptives. ***Combined oral contraceptives*** - **Combined oral contraceptives (COCs)** are the **most commonly used first-line medical treatment** for endometriosis, as they suppress ovulation and reduce estrogen production, thereby reducing endometrial lesion growth. - They help manage **endometriosis-associated pain** by decreasing menstrual flow and uterine contractions. - COCs are widely prescribed due to their efficacy, safety profile, and additional contraceptive benefits. *Letrozole* - **Letrozole** is an aromatase inhibitor that reduces local estrogen production and has shown efficacy in treating endometriosis, particularly in refractory cases. - However, it is **not commonly used as first-line therapy** due to potential side effects (bone density concerns, teratogenicity) and is typically reserved for cases resistant to conventional hormonal therapy. - It may be used in combination with progestins for better outcomes. *Mifepristone* - **Mifepristone** is an antiprogestin primarily used for medical abortion or in the treatment of Cushing's syndrome. - It works by blocking **progesterone receptors** and is not a standard treatment for endometriosis. *None of the above* - This option is incorrect because **combined oral contraceptives** are the most widely accepted and commonly used treatment for endometriosis.

Q: What condition is diagnosed using the Amsel criteria?

Bacterial vaginosis. ***Bacterial vaginosis*** - The **Amsel criteria** are specifically used for the clinical diagnosis of **bacterial vaginosis (BV)**. - The criteria include the presence of at least three of four findings: **homogeneous discharge**, **vaginal pH >4.5**, **positive whiff test**, and **clue cells** on microscopy. *Antiphospholipid antibody syndrome* - This syndrome is diagnosed based on **clinical criteria** (thrombosis, pregnancy morbidity) and the presence of persistent **antiphospholipid antibodies** (lupus anticoagulant, anti-cardiolipin, anti-β2-glycoprotein I antibodies). - It does not involve the use of the Amsel criteria. *Ovarian ectopic pregnancy* - Diagnosed primarily through **ultrasound imaging** showing a gestational sac or fetal heartbeat within the ovary, often accompanied by clinical symptoms like abdominal pain and vaginal bleeding. - This condition is not related to vaginal infections or the Amsel criteria. *HELLP Syndrome* - **HELLP syndrome** (Hemolysis, Elevated Liver enzymes, Low Platelets) is a severe obstetric complication usually occurring in pregnancy, diagnosed by **laboratory findings** of these specific abnormalities. - It is a systemic condition, not a vaginal infection, and does not use the Amsel criteria for diagnosis.

Question 1

Embryo gets implanted at what stage of development?

Accepted Answer

Blastocyst

Answer

Two cell stage

Answer

Four cell stage

Answer

Morula

Question 2

What is the most common type of conjoint twin?

Accepted Answer

Thoracopagus

Answer

Omphalopagus

Answer

Craniopagus

Answer

Rachipagus

Question 3

Uterine height is greater than gestational age of the patient in a case of all except -

Accepted Answer

IUGR

Answer

Fibroid uterus

Answer

Wrong dates

Answer

Polyhydramnios

Question 4

Following delivery, a tear involving the perineum and external anal sphincter with intact mucosa is classified as which grade?

Accepted Answer

Third degree

Answer

First degree

Answer

Second degree

Answer

Fourth degree

Question 5

Which of the following is NOT a cause of oligohydramnios?

Accepted Answer

Chorioangioma

Answer

Renal agenesis

Answer

Amnion nodosum

Answer

IUGR

Question 6

Which of the following statements about chorionic villus sampling is false?

Accepted Answer

Is performed only in second trimester of pregnancy

Answer

Can cause limb deformities

Answer

Is used for prenatal genetic diagnosis

Answer

Villi are collected from chorion frondosum

Question 7

A 28-year-old primigravida with 32 weeks of gestation presents with profuse vaginal discharge since yesterday. She was advised USG, which showed a single live intrauterine gestational sac with FL and AC corresponding to the weeks of gestation and AFI as adequate. What is the diagnosis?

Accepted Answer

Normal vaginal discharge

Answer

Candidiasis

Answer

Trichomoniasis

Answer

Preterm Premature Rupture of Membranes (PPROM)

Question 8

Poor prognostic factor for hydatidiform mole is -

Accepted Answer

WHO score > 8

Answer

Prior molar pregnancy

Answer

Metastasis to lung

Answer

No prior chemotherapy

Question 9

Which of the following drugs is commonly used in the treatment of endometriosis?

Accepted Answer

Combined oral contraceptives

Answer

None of the above

Answer

Letrozole

Answer

Mifepristone

Question 10

What condition is diagnosed using the Amsel criteria?

Accepted Answer

Bacterial vaginosis

Answer

Antiphospholipid antibody syndrome

Answer

Ovarian ectopic pregnancy

Answer

HELLP Syndrome

NEET-PG 2015

Anatomy

Obstetrics and Gynecology