Which of the following syndromes is least likely to be associated with obesity?

Sipple syndrome. ***Sipple syndrome*** - Sipple syndrome, also known as **multiple endocrine neoplasia type 2**, is primarily associated with **medullary thyroid carcinoma** and does not typically correlate with obesity. - It includes signs like **pheochromocytoma** and **hyperparathyroidism**, but obesity is not a prominent feature. *Cushing syndrome* - Cushing syndrome leads to **excess cortisol**, commonly resulting in weight gain and central obesity [1]. - Characteristic features include **moon facies**, **buffalo hump**, and easy bruising, all associated with obesity [1]. *Pickwinian syndrome* - Pickwinian syndrome, characterized by **severe obesity**, is a condition primarily affecting physical stature and weight. - It is linked to **hypoventilation** and sleep apnea, reinforcing the presence of obesity. *Prader willi syndrome* - Prader-Willi syndrome is marked by **insatiable hunger** leading to **obesity** due to hypothalamic dysfunction [2]. - Individuals with this condition also demonstrate **hypotonia** and developmental delays, commonly accompanied by obesity [2]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Endocrine System, pp. 1127-1129. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Central Nervous System Synapse, pp. 454-455. [Practice more General Medicine PYQs on OnCourse]

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NEET-PG 2015 — General Medicine

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NEET-PG 2015 General Medicine PYQs with Answers - Oncourse AI