NEET-PG 2013 Practice Questions

Q: All are seen in Behçet's syndrome except:

Pyoderma gangrenosum. ***Pyoderma gangrenosum*** - While Behçet's syndrome can involve skin lesions, **pyoderma gangrenosum** is not typically part of its diagnostic criteria or common manifestations. - Pyoderma gangrenosum is a distinct neutrophilic dermatosis characterized by rapidly enlarging, painful ulcers. *Erythema nodosum* - **Erythema nodosum** is a common dermatological manifestation in Behçet's syndrome, characterized by tender subcutaneous nodules, usually on the shins. - These lesions reflect the systemic inflammatory nature of the disease in various organs. *Genital ulcers* - **Genital ulcers** are one of the major diagnostic criteria for Behçet's syndrome, often painful and recurrent. - They tend to be deep and can form scars, appearing on the scrotum, penis, labia, or perianal area. *Oral ulcers* - **Recurrent oral aphthous ulcers** are the most common and often the initial symptom of Behçet's syndrome. - These ulcers are typically painful, varying in size, and can occur on any mucosal surface in the mouth.

Q: All are symptoms of morphine withdrawal except?

Fall in BP. ***Fall in BP*** - **Hypotension (fall in BP)** is **not** typically a symptom of opioid withdrawal; rather, **hypertension** can occur due to sympathetic overdrive. - Opioid withdrawal symptoms are primarily characterized by **hyperactivity** and increased sympathetic nervous system activity. *Mydriasis* - **Mydriasis (dilated pupils)** is a classic symptom of opioid withdrawal, resulting from reduced parasympathetic tone and increased sympathetic activity. - In contrast, opioid intoxication causes **miosis (pinpoint pupils)**. *Yawning* - **Yawning** is a very common and early symptom of opioid withdrawal, often accompanied by feelings of fatigue and restlessness. - It reflects generalized **autonomic dysregulation** during withdrawal. *Lacrimation* - **Lacrimation (tearing)** is another prominent autonomic symptom of opioid withdrawal. - This, along with rhinorrhea, contributes to the **"flu-like" symptoms** experienced during withdrawal.

Q: Which of the following is NOT a diagnostic criterion for drug dependence?

Early completion of tasks. ***Early completion of tasks*** - This is not a recognized diagnostic criterion for **drug dependence (substance use disorder)** according to standardized diagnostic manuals like the DSM-5. - While it might reflect an individual's productivity or efficiency, it has no direct link to the compulsive drug-seeking and use behaviors characteristic of dependence. *Tolerance* - **Tolerance** is a core criterion, defined as a need for markedly increased amounts of the substance to achieve intoxication or desired effect, or a markedly diminished effect with continued use of the same amount of the substance. - This indicates a physiological adaptation to the presence of the drug. *Withdrawal symptoms* - **Withdrawal symptoms** refer to the characteristic physiological and psychological symptoms that occur when a person stops or reduces their use of a substance after prolonged or heavy use. - The presence of a withdrawal syndrome or taking the substance (or a closely related one) to relieve or avoid withdrawal symptoms is a key diagnostic indicator. *Taking substance in larger amounts than intended* - This criterion reflects the **impaired control** over substance use, where the individual uses the substance more often or in larger quantities than they initially intended. - It demonstrates a loss of conscious regulation over drug intake, which is a hallmark of substance dependence.

Q: Which of the following is true regarding the treatment of cocaine withdrawal symptoms?

No specific drug. ***No specific drug*** - Currently, there is **no FDA-approved pharmacotherapy** for the treatment of cocaine withdrawal symptoms or for preventing relapse in cocaine dependence. - Management primarily focuses on **supportive care**, **psychotherapy** (cognitive behavioral therapy, contingency management), and addressing **co-occurring mental health disorders**. - Unlike alcohol or opioid withdrawal, cocaine withdrawal is not life-threatening and does not require specific medication. *Fluoxetine* - Fluoxetine is a **selective serotonin reuptake inhibitor (SSRI)** primarily used to treat depression and anxiety disorders. - While depression can be a symptom of cocaine withdrawal, fluoxetine has **not been shown to be effective** for reducing cocaine use or treating cocaine withdrawal specifically. - Multiple clinical trials have failed to demonstrate benefit for cocaine dependence treatment. *Antidepressants* - While various antidepressants (including desipramine, bupropion) have been investigated, there is **no strong evidence** to support their routine use as primary treatment for cocaine withdrawal or dependence. - Their effectiveness in this context is **limited and inconsistent** across studies. - They may be used to treat **co-occurring depressive disorders** but not as primary cocaine withdrawal treatment. *Benzodiazepines* - Benzodiazepines are primarily used to manage **acute anxiety and seizures** during withdrawal from GABAergic substances like **alcohol and sedatives**. - They are generally **not recommended** for cocaine withdrawal as cocaine withdrawal does not cause seizures or dangerous autonomic instability. - May be used only for **severe agitation** or **co-occurring alcohol withdrawal**, but carry their own dependence potential and do not address cocaine withdrawal itself.

Q: Which of the following is NOT a symptom of nicotine withdrawal?

Increased heart rate. ***Increased heart rate*** - **Increased heart rate** is NOT a symptom of nicotine withdrawal; rather, it is associated with **active nicotine use** due to nicotine's stimulant effects on the sympathetic nervous system. - During **nicotine withdrawal**, the heart rate typically **decreases or normalizes** as the body adjusts to the absence of nicotine's cardiovascular stimulation. - Nicotine acts as a sympathomimetic agent, causing tachycardia during use, but withdrawal does not produce increased heart rate. *Anxiety* - **Anxiety** is one of the most common and prominent symptoms of **nicotine withdrawal**. - As nicotine affects neurotransmitter systems (particularly dopamine, norepinephrine, and serotonin), cessation leads to neurochemical imbalances manifesting as anxiety, irritability, and restlessness. - This symptom typically peaks within the first week of cessation. *Hyperhidrosis* - **Hyperhidrosis** (excessive sweating) is actually a recognized symptom of **nicotine withdrawal**. - Increased sweating can occur as part of the autonomic nervous system dysregulation during the withdrawal period. - This is included among the physical withdrawal symptoms in standard diagnostic criteria. *Weight gain* - **Weight gain** is a well-documented and common consequence of **nicotine withdrawal**. - This occurs due to increased appetite, decreased metabolic rate (as nicotine's metabolic-enhancing effects cease), and behavioral substitution of smoking with eating. - Average weight gain is approximately 4-5 kg in the months following cessation.

Q: Which of the following conditions does not typically involve delusions?

OCD. ***OCD*** - **Obsessive-compulsive disorder** is characterized by recurrent, intrusive **thoughts (obsessions)** and repetitive **behaviors (compulsions)**, which the individual typically recognizes as irrational. - While patients with severe OCD may have **poor insight**, they generally do not experience **delusions**, which are fixed, false beliefs held despite evidence to the contrary. *Delirium* - **Delirium** is an acute, fluctuating disturbance of consciousness resulting from medical conditions or substance intoxication/withdrawal, often accompanied by **psychotic symptoms** including **delusions** and **hallucinations**. - The rapid onset and global cognitive impairment make **delusions** a common feature. *Schizophrenia* - **Schizophrenia** is a severe mental disorder characterized by **psychotic symptoms**, with **delusions** being one of the hallmark positive symptoms. - These **delusions** often include **persecutory**, **grandiose**, or **somatic themes**, among others. *Alcohol withdrawal* - Severe **alcohol withdrawal** can lead to **delirium tremens (DTs)**, which is associated with **psychotic symptoms** such as **delusions** and vivid **hallucinations** (often visual or tactile). - These **delusions** are often **persecutory** or referential in nature and contribute to the patient's fear and agitation.

Q: Which of the following is not a feature of psychosis?

Preserved contact with reality. ***Preserved contact with reality*** - Psychosis is fundamentally characterized by a **loss of contact with reality**, making this option a defining non-feature of the condition. - Individuals experiencing psychosis often have profound difficulties distinguishing between what is real and what is not. *Loss of insight* - **Lack of insight** into one's own mental illness is a hallmark feature of psychosis, meaning the affected individual may not recognize their thoughts or perceptions as abnormal. - This symptom contributes to the difficulty in engaging individuals with psychosis in treatment. *Presence of delusions* - **Delusions** are fixed, false beliefs that are resistant to reason or evidence, and they are a core positive symptom of psychosis. - These beliefs are often bizarre and can significantly impair an individual's functioning and perception of reality. *Personality disturbances* - While not a primary diagnostic criterion, **personality disturbances** can be associated with psychotic disorders. - Changes in personality, mood, and behavior may occur as a result of the psychotic experience or the underlying illness.

Q: Which of the following is NOT a feature of neurosis?

Personality disturbances. ***Personality disturbances*** - While neurosis can cause significant distress and impact functioning, it does not typically involve **fundamental alterations in personality structure or identity**. - **Personality disorders**, not neuroses, are characterized by deeply ingrained, inflexible, and maladaptive patterns of perceiving, thinking, and behaving that deviate markedly from cultural expectations. *Symptoms cause subjective distress* - A core characteristic of neurosis is that the individual experiences significant **emotional suffering** and discomfort due to their symptoms, such as anxiety, phobias, or obsessions. - This **subjective distress** is often a primary motivator for seeking treatment. *Contact with reality preserved* - Individuals with neurosis maintain their ability to **distinguish between internal experiences and external reality**, unlike in psychosis where this distinction is lost. - They may understand that their fears or anxieties are irrational, but they are unable to control them. *Insight is maintained* - People with neurosis generally have some level of **awareness** that they have a problem or that their symptoms are unreasonable or excessive. - This **insight** allows them to recognize the need for help and engage in therapeutic processes.

Q: Which of the following is NOT considered one of Bleuler's fundamental symptoms of schizophrenia?

Delusions. ***Delusions*** - **Delusions** are considered a **first-rank symptom** of schizophrenia according to Schneider, but not one of Bleuler's fundamental "4 A's". - Bleuler classified delusions as **accessory symptoms**, which are variable and not always present, unlike fundamental symptoms. *Loosening of associations* - This is one of Bleuler's **"4 A's"**, representing a disturbance in the logical flow of thought, leading to incoherent speech and fractured thinking. - Bleuler saw this as a core cognitive dysfunction in schizophrenia. *Affect disturbances* - This refers to **inappropriate affect** (e.g., laughing at a funeral) or **blunted/flattened affect**, which is another of Bleuler's "4 A's." - It signifies a disruption in the normal experience and expression of emotions. *Autism* - Bleuler's term **"autism"** (or autismus) refers to a pathological self-preoccupation, withdrawal from social interaction, and an immersion in one's own internal world. - This is also one of Bleuler's **"4 A's"**, highlighting a foundational disturbance in social engagement.

Q: Which of the following is not considered a core diagnostic criterion for schizophrenia according to DSM-5?

Social withdrawal. ***Social withdrawal*** - While **social withdrawal** is a common clinical feature and often reflects negative symptoms in schizophrenia, it is **not specifically listed** as one of the **five core diagnostic criteria (Criterion A)** in DSM-5. - The five core symptom domains are: delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior, and negative symptoms (diminished emotional expression or avolition). - Social withdrawal may be a manifestation of negative symptoms or part of **social/occupational dysfunction (Criterion B)**, but it is not itself a distinct core diagnostic criterion. *Catatonia* - **Catatonic behavior** (such as stupor, catalepsy, waxy flexibility, posturing, or mutism) is explicitly included as part of the **fourth core diagnostic criterion**: "Grossly disorganized or catatonic behavior." - This makes it one of the five primary symptom domains in **Criterion A** of DSM-5. - Note: "Catatonia" as a **specifier** (requiring 3+ out of 12 symptoms) is different from catatonic behavior as a core symptom. *Hallucinations* - **Hallucinations** (most commonly auditory, but can be visual, tactile, olfactory, or gustatory) are the **second core diagnostic criterion** in DSM-5. - At least **two of the five core symptoms** must be present, and hallucinations fulfill this requirement as a key **positive symptom**. *Disorganized speech* - **Disorganized speech** (formal thought disorder) is the **third core diagnostic criterion** for schizophrenia. - Characterized by **derailment, tangentiality, incoherence, or loose associations**, it reflects significant disruption in organized thinking and communication.

Question 1

All are seen in Behçet's syndrome except:

Accepted Answer

Pyoderma gangrenosum

Answer

Erythema nodosum

Answer

Genital ulcers

Answer

Oral ulcers

Question 2

All are symptoms of morphine withdrawal except?

Accepted Answer

Fall in BP

Answer

Yawning

Answer

Lacrimation

Answer

Mydriasis

Question 3

Which of the following is NOT a diagnostic criterion for drug dependence?

Accepted Answer

Early completion of tasks

Answer

Taking substance in larger amounts than intended

Answer

Tolerance

Answer

Withdrawal symptoms

Question 4

Which of the following is true regarding the treatment of cocaine withdrawal symptoms?

Accepted Answer

No specific drug

Answer

Fluoxetine

Answer

Antidepressants

Answer

Benzodiazepines

Question 5

Which of the following is NOT a symptom of nicotine withdrawal?

Accepted Answer

Increased heart rate

Answer

Anxiety

Answer

Hyperhidrosis

Answer

Weight gain

Question 6

Which of the following conditions does not typically involve delusions?

Accepted Answer

OCD

Answer

Delirium

Answer

Alcohol withdrawal

Answer

Schizophrenia

Question 7

Which of the following is not a feature of psychosis?

Accepted Answer

Preserved contact with reality

Answer

Loss of insight

Answer

Personality disturbances

Answer

Presence of delusions

Question 8

Which of the following is NOT a feature of neurosis?

Accepted Answer

Personality disturbances

Answer

Symptoms cause subjective distress

Answer

Contact with reality preserved

Answer

Insight is maintained

Question 9

Which of the following is NOT considered one of Bleuler's fundamental symptoms of schizophrenia?

Accepted Answer

Delusions

Answer

Loosening of associations

Answer

Affect disturbances

Answer

Autism

Question 10

Which of the following is not considered a core diagnostic criterion for schizophrenia according to DSM-5?

Accepted Answer

Social withdrawal

Answer

Catatonia

Answer

Hallucinations

Answer

Disorganized speech

NEET-PG 2013

Internal Medicine

Pharmacology

Psychiatry