Biochemistry
1 questionsIn which of the following conditions is a Barr body absent in females?
NEET-PG 2012 - Biochemistry NEET-PG Practice Questions and MCQs
Question 891: In which of the following conditions is a Barr body absent in females?
- A. 46 XX genome
- B. 45 X0 genome (Correct Answer)
- C. 47 XXX
- D. None of the options
Explanation: ***45 X0 genome*** - A Barr body is a **condensed, inactivated X chromosome** found in somatic cells of females with at least two X chromosomes. - Individuals with a **45 X0 genome** (Turner Syndrome) have only one X chromosome, therefore no Barr body is formed. *46 XX genome* - Individuals with a **46 XX genome** are typical females and will have one Barr body per somatic cell, as one of the two X chromosomes is inactivated. - This is the normal female karyotype. *47 XXX* - Individuals with a **47 XXX genome** (triple X syndrome) have two Barr bodies per somatic cell, as two of their three X chromosomes are inactivated. - The number of Barr bodies is typically one less than the number of X chromosomes. *None of the options* - This option is incorrect because the 45 X0 genome indeed leads to the absence of a Barr body in females. - There is a specific condition listed among the options where a Barr body is absent.
Internal Medicine
1 questionsWhich of the following statements about Sickle Cell Anemia is FALSE?
NEET-PG 2012 - Internal Medicine NEET-PG Practice Questions and MCQs
Question 891: Which of the following statements about Sickle Cell Anemia is FALSE?
- A. There is a positive correlation between HBS and polymerization of HBS (Correct Answer)
- B. Recurrent infections is the most common cause of death
- C. Patients require frequent blood transfusions
- D. Patients usually present before the age of 6 months
Explanation: ***There is a positive correlation between HBS and polymerization of HBS*** - This statement is false because the polymerization of **hemoglobin S (HbS)** is reduced as HbS levels decrease and is increased as HbS levels increase. Therefore, there is a **direct correlation**, not a positive one, where higher levels of HbS lead to more polymerization and sickling. - The disease is caused by the **polymerization of deoxyhemoglobin S**, which distorts red blood cells into a sickle shape, leading to vaso-occlusion and hemolysis [1]. *Recurrent infections is the most common cause of death* - **Recurrent infections** are indeed a leading cause of morbidity and mortality in sickle cell anemia patients, particularly in children due to **functional asplenia**. [1] - **Splenic dysfunction** impairs the ability to clear encapsulated bacteria, increasing the risk of severe infections like **pneumonia** and **meningitis**. *Patients require frequent blood transfusions* - **Frequent blood transfusions** are a common treatment strategy for sickle cell anemia to manage complications such as severe anemia, acute chest syndrome, and stroke prevention [1]. - **Chronic transfusion therapy** helps to suppress abnormal sickle cell production and dilute existing sickle cells, thereby reducing vaso-occlusive crises. *Patients usually present before the age of 6 months* - Patients with sickle cell anemia typically become symptomatic after 6 months of age, when **fetal hemoglobin (HbF)** levels decline. - **HbF protects** against sickling, so symptoms like **dactylitis** and **splenic sequestration** usually manifest once HbF is replaced by HbS [1].
Microbiology
1 questionsMost common bacterial cause of acute parotitis -
NEET-PG 2012 - Microbiology NEET-PG Practice Questions and MCQs
Question 891: Most common bacterial cause of acute parotitis -
- A. Staphylococcus Aureus (Correct Answer)
- B. Klebsiella
- C. Streptococcus Viridans
- D. Streptococcus Pneumoniae
Explanation: ***Staphylococcus Aureus*** - **_Staphylococcus aureus_** is the most frequent bacterial pathogen isolated in cases of **acute bacterial parotitis**. [2] - It often causes ascending infection from the oral cavity, leading to inflammation and suppuration of the parotid gland. [1] *Streptococcus Pneumonia* - While **_Streptococcus pneumoniae_** can cause various infections, it is not the primary cause of acute bacterial parotitis. - Its infections more commonly manifest as **pneumonia**, otitis media, or meningitis. *Klebsiella* - **_Klebsiella_** species are typically associated with **nosocomial infections**, particularly urinary tract infections and pneumonia. - They are a relatively uncommon cause of acute parotitis compared to _S. aureus_. *Streptococcus Viridans* - **_Streptococcus viridans_** group bacteria are common commensal organisms of the oral cavity and are often implicated in **dental caries** and **endocarditis**. - They are not a usual cause of acute bacterial parotitis.
Obstetrics and Gynecology
1 questionsWhat is thelarche?
NEET-PG 2012 - Obstetrics and Gynecology NEET-PG Practice Questions and MCQs
Question 891: What is thelarche?
- A. Breast development in boys during puberty
- B. Breast enlargement during pregnancy
- C. Breast enlargement due to hormonal therapy in postmenopausal women
- D. Hormone-related breast development in girls (Correct Answer)
Explanation: ***Hormone-related breast enlargement in girls*** - **Thelarche** specifically refers to the first sign of puberty in girls, which is the **onset of breast development**. - This development is primarily driven by the action of **estrogen** on breast tissue. *Breast development in boys during puberty* - This condition is known as **gynecomastia**, which is distinguishable from thelarche observed in girls. - While also hormone-related, **gynecomastia** often involves an imbalance between estrogen and androgens. *Breast enlargement during pregnancy* - Breast enlargement during pregnancy is a normal physiological change in preparation for lactation, driven by a surge in various hormones like **estrogen, progesterone, and prolactin**. - It is distinct from the initial, puberty-related breast development in girls. *Breast enlargement due to hormonal therapy in postmenopausal women* - This is an induced effect of **exogenous hormones** (e.g., hormone replacement therapy) and not a natural developmental stage like thelarche. - It is a side effect of medication, not the start of puberty.
Pediatrics
2 questionsMaximum concentration of dextrose that can be given through peripheral vascular line in neonate?
The recommended ambient temperature for NICU is
NEET-PG 2012 - Pediatrics NEET-PG Practice Questions and MCQs
Question 891: Maximum concentration of dextrose that can be given through peripheral vascular line in neonate?
- A. 5%
- B. 10%
- C. 12.5% (Correct Answer)
- D. 25%
Explanation: ***12.5%*** - A maximum dextrose concentration of **12.5%** can typically be administered safely via a **peripheral intravenous line** in neonates. - Higher concentrations risk causing **osmotic damage** to the peripheral vein, leading to **phlebitis** and **thrombosis**. *5%* - While safe, a **5% dextrose** solution may not provide adequate caloric support for many neonates, especially those requiring significant nutritional intake. - It is used for basic hydration and to prevent hypoglycemia but often needs supplementation or higher concentrations for sustained feeding. *10%* - A **10% dextrose** solution is commonly used in neonates via peripheral lines, but concentrations up to 12.5% are generally considered the safe upper limit for extended use. - Exceeding 10% can increase the risk of phlebitis, although it is less severe than with 25%. *25%* - A **25% dextrose** concentration is highly hypertonic and should **never be administered through a peripheral line** in neonates due to the high risk of severe **phlebitis**, **vein damage**, and even **tissue necrosis** if extravasation occurs. - Such high concentrations require a **central venous catheter**.
Question 892: The recommended ambient temperature for NICU is
- A. 20-22° C
- B. 22-26° C (Correct Answer)
- C. 26-30° C
- D. 30-35° C
Explanation: ***22-26° C*** - Maintaining an ambient temperature of **22-26°C** in the NICU is crucial for preventing **cold stress** in neonates. - This temperature range helps to maintain the baby's **core body temperature**, reducing metabolic demands and ensuring optimal thermal regulation. *20-22° C* - While this might be a comfortable room temperature for adults, it is generally **too cold** for newborns in the NICU. - Temperatures below the recommended range can lead to significant **cold stress**, increasing oxygen consumption and metabolic rate in vulnerable infants. *26-30° C* - This temperature range is generally **too warm** for a NICU environment. - Excessive warmth can lead to **hyperthermia** and sweating, which increases fluid loss and can be detrimental to a neonate's health. *30-35°C* - This temperature is **dangerously high** for neonates in the NICU. - Such high temperatures would significantly increase the risk of **hyperthermia, dehydration**, and other severe complications, compromising the infant's well-being.
Pharmacology
1 questionsWhich drug is used as a treatment for sickle cell anemia by promoting fetal hemoglobin production?
NEET-PG 2012 - Pharmacology NEET-PG Practice Questions and MCQs
Question 891: Which drug is used as a treatment for sickle cell anemia by promoting fetal hemoglobin production?
- A. Trypsin
- B. Hydroxyurea (Correct Answer)
- C. L-glutamine
- D. Glucose 6-phosphate dehydrogenase
Explanation: ***Hydroxyurea*** - **Hydroxyurea** is the primary drug used to treat sickle cell anemia by promoting **fetal hemoglobin (HbF)** production - It is a **ribonucleotide reductase inhibitor** that increases HbF levels, which reduces sickling of red blood cells - Clinical benefits include reduced frequency of **vaso-occlusive crises**, decreased need for transfusions, and improved survival - Mechanism: Increases **HbF** production, which dilutes the abnormal **HbS** and prevents polymerization *Trypsin* - **Trypsin** is a **proteolytic enzyme** involved in protein digestion in the gastrointestinal tract - It has no role in the treatment of **sickle cell anemia** or in promoting **fetal hemoglobin** production *L-glutamine* - **L-glutamine** is an **amino acid** (not a drug that promotes HbF) approved for sickle cell disease - Its mechanism involves reducing **oxidative stress** by increasing NAD+ levels and improving red blood cell energy metabolism - It reduces complications but does not primarily work by increasing **fetal hemoglobin** production *Glucose 6-phosphate dehydrogenase* - **G6PD** is an **enzyme** in the **pentose phosphate pathway**, not a therapeutic agent - **G6PD deficiency** causes hemolytic anemia but is unrelated to sickle cell disease treatment or fetal hemoglobin production
Radiology
1 questionsParrot beak appearance is seen in which of the following conditions?
NEET-PG 2012 - Radiology NEET-PG Practice Questions and MCQs
Question 891: Parrot beak appearance is seen in which of the following conditions?
- A. Volvulus (Correct Answer)
- B. Rectal atresia
- C. CA colon
- D. Intussusception
Explanation: ***Volvulus*** - A **parrot beak** appearance, or bird's beak sign, is characteristic of a **volvulus** on barium enema or CT imaging, representing the twisted lumen of the bowel. - This finding indicates a **torsion** of a segment of the bowel, which can lead to obstruction and ischemia. *Intussusception* - Intussusception typically presents with a **"target sign"** or **"donut sign"** on ultrasound, indicating concentric layers of bowel within bowel. - The classic presentation is a **"currant jelly stool"** and a palpable **sausage-shaped mass**. *Rectal atresia* - Rectal atresia involves a **complete blockage** or absence of the rectum, preventing passage of stool. - Imaging typically shows a **dilated colon** proximal to the atretic segment, without a specific "parrot beak" appearance. *CA colon* - Colon cancer (CA colon) appears as a **filling defect** or an **"apple core" lesion** on barium enema due to tumoral constriction. - It does not present with a "parrot beak" sign, which is indicative of a twisted bowel segment.
Surgery
2 questionsBest gas used for creating pneumoperitoneum at laparoscopy is:
The term 'raspberry tumor' is most commonly associated with which of the following conditions?
NEET-PG 2012 - Surgery NEET-PG Practice Questions and MCQs
Question 891: Best gas used for creating pneumoperitoneum at laparoscopy is:
- A. N2
- B. CO2 (Correct Answer)
- C. N2O
- D. O2
Explanation: ***CO2*** - **Carbon dioxide** is rapidly absorbed and expelled by the respiratory system, minimizing the risk of **gas embolism**. - It is **non-flammable**, which is crucial in a surgical environment where electrosurgical devices are often used. - CO2 is **highly soluble in blood**, allowing rapid clearance if venous absorption occurs. *N2* - **Nitrogen** is not ideal for pneumoperitoneum as its poor solubility in blood leads to a significant risk of **gas embolism**. - **Increased nitrogen pockets** can create complications that make it a poor choice. *O2* - **Oxygen** poses a significant **fire hazard** in the presence of electrosurgical instruments. - It **supports combustion**, making the surgical field dangerous when using electrocautery or laser devices. *N2O* - **Nitrous oxide** supports **combustion**, making it unsafe for use with electrosurgical devices. - It can also diffuse into **bowel loops**, causing distension and obstructing visibility, which is undesirable during laparoscopy.
Question 892: The term 'raspberry tumor' is most commonly associated with which of the following conditions?
- A. Umbilical fistula
- B. Meckel’s diverticulum
- C. Umbilical granuloma (Correct Answer)
- D. Umbilical adenoma
Explanation: ***Umbilical granuloma*** - An **umbilical granuloma** is a common condition in newborns, presenting as a soft, red, moist growth at the umbilicus after the umbilical cord detaches. - Its characteristic appearance, resembling a small red berry, has led to the descriptive term "**raspberry tumor**." *Umbilical fistula* - An **umbilical fistula** is an abnormal connection that can occur between the intestine or bladder and the umbilicus, leading to the discharge of stool or urine from the umbilicus. - It does not present as a fleshy, raspberry-like growth, but rather as an opening with discharge. *Meckel’s diverticulum* - **Meckel's diverticulum** is a remnant of the **vitelline duct**, typically found on the anti-mesenteric border of the ileum, and is a congenital anomaly of the small intestine. - It is an internal structure and does not manifest externally at the umbilicus as a "raspberry tumor." *Umbilical adenoma* - An **umbilical adenoma** is a rare tumor of the umbilicus, often a remnant of the **vitelline duct** or **urachus**, which can present as a reddish mass. - While it can be a reddish mass, the specific term "raspberry tumor" is not commonly associated with umbilical adenoma but rather with umbilical granuloma due to its very distinct granular appearance.