HIV — Flashcards

Flashcard 21: Coreceptors for Macrophages and T-Cell in HIV infection: 1. Macrophage: CD4 and _____ 2. T-Cell: CD4 + CXCR4

Answer: CCR5

Extra:  https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 22: Which immune cell(s) secretes IL-3?_____

Answer: T cells (both Th1 and Th2)

Flashcard 23: Which immune cell has the cell surface protein CD4 and CD25? _____

Answer: Regulatory T cells

Flashcard 24: Which immune cell has the cell surface protein CXCR4? _____

Answer: T cells (late HIV infection)

Flashcard 25: Which immune cell has the cell surface protein CD40L? _____

Answer: Helper T cells

Flashcard 26: Which immune cell has the cell surface protein CCR5? _____

Answer: Macrophages (early HIV infection)

Flashcard 27: Which gene is mutated in HIV protease inhibitor resistance?_____

Answer: pol gene

Flashcard 28: _____ is the outer glycoprotein of HIV

Answer: gp120

Flashcard 29: _____ is the transmembrane protein of HIV, mediating viral-cell fusion and syncytia formation

Answer: gp41

Flashcard 30: Which envelope protein on HIV binds the CD4 molecule and a chemokine receptor (CXCR4 or CCR5)?_____

Answer: gp120