HIV cure research — Flashcards

Flashcard 1: Individuals with _____-zygous CCR5 allele mutations are resistant to HIV infection

Answer: homo

Flashcard 2: Which viral gene in HIV codes for its Reverse Transcriptase?_____

Answer: pol

Flashcard 3: Reactivation of CMV from mononuclear cells occurs via _____

Answer: immunosuppression (organ transplant, AIDS patients)

Flashcard 4: Which two regulatory proteins of HIV are required for viral replication?_____

Answer: Rev and Tat

Flashcard 5: Which immune cell has the cell surface protein CCR5? _____

Answer: Macrophages (early HIV infection)

Flashcard 6: Mutations in the _____ gene enable HIV to escape from host neutralizing antibodies

Answer: env

Flashcard 7: _____ is a regulatory protein of HIV that transcriptionally activates other viral genes.

Answer: Tat

Flashcard 8: _____ is the transmembrane protein of HIV, mediating viral-cell fusion and syncytia formation

Answer: gp41

Flashcard 9: What is the causative agent and primary pathology of Progressive Multifocal Leukoencephalopathy (PML) in AIDS patients?

Answer: Causative agent: JC virus Pathology: Reactivation causing destruction of oligodendrocytes and CNS demyelination.

Extra: PML is a rapidly progressive, usually fatal disease. It occurs due to the reactivation of the JC virus (Polyomavirus) in immunocompromised states, specifically when CD4+ counts are low in AIDS patients. It involves multiple non-enhancing white matter lesions on MRI.

Flashcard 10: The _____ blot *used to be* the confirmatory test for HIV after a positive ELISA

Answer: Western

Extra:   https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki