HIV transmission and epidemiology — Flashcards

Flashcard 1: _____ is a regulatory protein of HIV that regulates viral RNA transport of unspliced viral transcripts out of the nucleus

Answer: Rev

Flashcard 2: _____ is a regulatory protein of HIV that transcriptionally activates other viral genes.

Answer: Tat

Flashcard 3: Which viral gene in HIV codes for the p24 capsid protein?_____

Answer: gag

Flashcard 4: Which viral gene in HIV codes for the p17 matrix protein?_____

Answer: gag

Flashcard 5: Does HIV have an envelope?_____

Answer: Yes

Flashcard 6: _____ is the transmembrane protein of HIV, mediating viral-cell fusion and syncytia formation

Answer: gp41

Flashcard 7: What is the causative agent and primary pathology of Progressive Multifocal Leukoencephalopathy (PML) in AIDS patients?

Answer: Causative agent: JC virus Pathology: Reactivation causing destruction of oligodendrocytes and CNS demyelination.

Extra: PML is a rapidly progressive, usually fatal disease. It occurs due to the reactivation of the JC virus (Polyomavirus) in immunocompromised states, specifically when CD4+ counts are low in AIDS patients. It involves multiple non-enhancing white matter lesions on MRI.

Flashcard 8: The _____ blot *used to be* the confirmatory test for HIV after a positive ELISA

Answer: Western

Extra:   https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 9: Which envelope protein on HIV binds the CD4 molecule and a chemokine receptor (CXCR4 or CCR5)? _____

Answer: gp120

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 10: Which HIV gene encodes for the virion p24 (Capsid) and p17 (Matrix) core proteins? _____

Answer: gag

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki