HIV structure and replication cycle — Flashcards

Flashcard 1: Which gene is mutated in HIV protease inhibitor resistance?_____

Answer: pol gene

Flashcard 2: HIV has _____ strands of RNA in its genome

Answer: two

Flashcard 3: Mutations in the _____ gene enable HIV to escape from host neutralizing antibodies

Answer: env

Flashcard 4: Which viral gene in HIV codes for the surface glycoproteins gp120 and gp41?_____

Answer: env

Flashcard 5: Which envelope protein on HIV binds the CD4 molecule and a chemokine receptor (CXCR4 or CCR5)?_____

Answer: gp120

Flashcard 6: Which viral gene in HIV codes for the p17 matrix protein?_____

Answer: gag

Flashcard 7: Which viral gene in HIV codes for its Integrase?_____

Answer: pol

Flashcard 8: What is the causative agent and primary pathology of Progressive Multifocal Leukoencephalopathy (PML) in AIDS patients?

Answer: Causative agent: JC virus Pathology: Reactivation causing destruction of oligodendrocytes and CNS demyelination.

Extra: PML is a rapidly progressive, usually fatal disease. It occurs due to the reactivation of the JC virus (Polyomavirus) in immunocompromised states, specifically when CD4+ counts are low in AIDS patients. It involves multiple non-enhancing white matter lesions on MRI.

Flashcard 9: The _____ blot *used to be* the confirmatory test for HIV after a positive ELISA

Answer: Western

Extra:   https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 10: Which envelope protein on HIV binds the CD4 molecule and a chemokine receptor (CXCR4 or CCR5)? _____

Answer: gp120

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki