Lipid metabolism — Flashcards

Flashcard 181: Treatment for medium chain acyl-CoA dehydrogenase deficiency includes avoiding _____

Answer: fasting

Flashcard 182: Can mineralocorticoids still be produced if the mineralocorticoid pathway is blocked below the level of DOC (i.e. absence of 11β-hydroxylase or aldosterone synthase)? _____

Answer: Yes, 11-deoxycorticosterone (DOC) and corticosterone both have mineralocorticoid activity

Flashcard 183: Apoprotein A-1 is an activator of the enzyme _____

Answer: LCAT (lecithin cholesterol acyltransferase)

Flashcard 184: Intracellular accumulation of triglycerides and FFAs contribute to insulin resistance in obesity via _____

Answer: inhibition of insulin signaling

Flashcard 185: Fatty acyl-carnitine is transported from the intermembrane space into the mitochondrial matrix via the _____

Answer: carnitine-acylcarnitine translocase

Flashcard 186: The first intermediate in cholesterol synthesis is _____ (from HMG CoA)

Answer: mevalonate

Extra: Sketchy Pharmacology: Blood & Inflammation (Dyslipidemia drugs)

Flashcard 187: Which female sex steroid is responsible for female fat distribution? _____

Answer: Estrogen

Flashcard 188: HDL delivers cholesterol esters directly to the liver via _____ receptors

Answer: scavenger receptor B-1

Extra: Sketchy Pharmacology: Blood & Inflammation (Dyslipidemia drugs)

Flashcard 189: Once in the vicinity of the liver, the chylomicron remnant binds the _____ receptor via apoprotein E

Answer: remnant

Flashcard 190: What substrate accumulates in the lysosomes of a patient with Gaucher disease? _____

Answer: Glucocerebroside

Extra: Atlas: