Pharmacokinetics and Pharmacodynamics — Flashcards

Nonbenzodiazepine hypnotics have a _____ duration of action due to rapid metabolism by the liver

The main _____ pregabalin has over gabapentin is that it is more bioavailable

Hint: advantage/disadvantage

All barbiturates (thiopentone, thiamylal, methohexital) other than _____ are metabolized by liver

Inhaled anesthetics with _____ solubility in blood have a faster onset of action

Colchicine works by inhibiting intracellular _____ polymerization through binding and stabilizing tubulin

The _____ of an inhaled anesthetic may also be referred to as the blood:gas partition coefficient

Mechanism of action of ivermectin primarily involves activation of _____-gated chloride channels found only in the invertebrates

Colchicine binds _____, preventing polymerization of microtubules

Aminoglycosides are _____ compounds and are excreted usually unchanged in the urine

Hint: polar/non-polar

_____ and ribavirin inhibit IMP dehydrogenase, preventing conversion of IMP to GMP (purine synthesis)