Pharmacokinetics and Pharmacodynamics — Flashcards

Typical antipsychotics have _____ lipid solubility and thus long half lives

Aspirin at _____ doses decreases uric acid reabsorption in the renal tubules

Antihistamines_____ generation H1 receptor antagonists may antagonize muscarinic receptors, leading to significant anti-cholinergic effects

Drugs that are more _____ and have a higher volume of distribution are preferentially processed by the liver

Dialysis is _____ in removing the drugs if they are sufficiently present in the free form in the plasma*AVOID dialysis?

All statins, except for _____, are metabolized by cytochrome p450

_____ drugs generally bind to plasma albumin in the blood

At _____ urine pH, the B form of a weak base exists, thus decreasing excretion

About _____% of phenytoin is bound to plasma proteins -mainly albumin

Pegloticase converts _____ into water soluble allantoin