Pharmacokinetics and Pharmacodynamics — Flashcards

In first-order kinetics, a drug infused at a constant rate takes _____ - 5 half-lives to reach steady state

Aminoglycosides exert _____-dependent killing and a long post-antibiotic effect

Hint: time/concentration

Cocaine is metabolised by _____ as well as the liver (primary)

Typical antipsychotics have _____ lipid solubility and thus long half lives

Pregabalin is a gabapentinoid that works by binding the _____ subunit of N-type voltage gated calcium channels

Plasma levels of thiopental decrease rapidly due to redistribution to _____ and adipose

Thiopental is a barbiturate with a rapid onset and short duration of action due to high potency, and high amount of _____ionized fraction and high lipid solubility

_____ is an mTOR inhibitor that binds FKBP

Oral nitrate preparations require _____ dosing due to first pass metabolism

_____ is a dipeptidyl-peptidase-4 (DPP-4) inhibitor eliminated by the hepatobiliary route.