General Pharmacology — Flashcards

Flashcard 1: Freeze sensitive vaccines are: No answer _____

Answer: :)

Flashcard 2: rubella vaccine(MMR) uses _____ strain

Answer: wistar RA27/3

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Flashcard 3: Td vaccine contains _____ LF units of diptheria content

Answer: <2

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Flashcard 4: In IPV,lowest antibody production is with _____ serotype

Answer: P3

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Flashcard 5: _____ is protein based recombinant type vaccine for malaria

Answer: mosquirix

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Flashcard 6: ARV anti rabies vaccine is stored at _____ temperature

Answer: 2-8 deg. celsius

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Flashcard 7: _____ is the most heat sensitive  raw vaccine

Answer: OPV

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Flashcard 8: Rhazes was known for contributions in _____

Answer: pharmacology and pediatrics

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Flashcard 9: MOA of intrauterine devices(IUD)

Answer: inhibits fertilization and inhibits implantation fert.>implantation centrchroman only to block only implantation

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Flashcard 10: MOA for insect growth regulators is

Answer: 1.inhibit chitin devlopment 2.mimic mosquito hormines to inhibit adult maturation

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Flashcard 11: mala N contains _____ tablets and mala D contains _____ tablets

Answer: 21

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Flashcard 12: 1. Identify & Use → _____

Answer: Pyrethrum, Anti-adult insecticide, Nerve poison

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Flashcard 13: _____ was the goddess of curative medicine

Answer: panacea

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Flashcard 14: function of preservative in a vaccine is to _____

Answer: prevent contamination of vaccine

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Flashcard 15: _____ is the most commonly used buffer in vaccines

Answer: sodium chloride

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Flashcard 16: dose route and site of adm. of DPT vaccine

Answer: 0.5 ml I.M. left anterolateral thigh

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Flashcard 17: _____ is the most freeze sensitive vaccine

Answer: Hep B

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Flashcard 18: route of administration of Vi polysaccharide vaccine is _____

Answer: injectable

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Flashcard 19: _____ is used as dilutent in JE vaccine

Answer: phosphate buffer

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Flashcard 20: _____ is the most heat sensitive vaccine

Answer: rBCG

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Flashcard 21: _____ surfactant is used in tuberculin test

Answer: tween 80

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Flashcard 22: CCID(cell culture infective dose 50%) for measles and rubella in MMR vaccine should be _____

Answer: >1000

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Flashcard 23: pyrethrum is a natural extract from _____

Answer: chrysenthamum

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Flashcard 24: mala N and mala D tablets contain _____ _____

Answer: 30 ug ethinyl estradiol 

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Flashcard 25: gastric buffer is used in _____ vaccine

Answer: cholera

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Flashcard 26: centchroman is given under name of  _____

Answer: Chhaya

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Flashcard 27: _____ and blosozumab are monoclonal antibodies against sclerostin

Answer: Romosozumab

Flashcard 28: The therapeutic index is calculated by _____/ED50

Answer: TD50

Flashcard 29: Acetazolamide causes decreased production of _____, which is useful in the management of pseudotumor cerebri

Answer: CSF

Flashcard 30: _____ inhibitors are used in glaucoma and act by relaxing the trabecular meshwork.

Answer: Rho kinase (ROCK)

Flashcard 31: _____ (e.g. caffeine) are inhibitors of the enzyme phosphodiesterase (PDE), which normally degrades cAMP into 5' AMP

Answer: Methyl xanthines

Flashcard 32: diabetes_____ insulin is the only insulin that can be administered IV

Answer: Regular

Flashcard 33: Drugs that act on microtubules may be remembered with the mnemonic "Microtubules Get Constructed Very Poorly":M: _____G: Griseofulvin (antifungal) C: Colchicine (antigout) V: Vincristine/Vinblastine (anticancer)P: Palcitaxel (anticancer)

Answer: Mebendazole (antihelminthic)

Flashcard 34: Glucocorticoids may have anti-inflammatory effects by inducing the synthesis of _____, an inhibitor of phospholipase A2

Answer: lipocortin

Flashcard 35: _____ is a read-through agent, used in the treatment of Duchenne muscular dystrophy

Answer: Ataluren

Flashcard 36: _____ inhibits the enzyme dehydropeptidase I in the kidneys

Answer: Cilastatin

Flashcard 37: _____ is a rho kinase inhibitor

Answer: Netarsudil

Flashcard 38: First Aid Pharmacology: Neuro/Psych Drugs with increased solubility in _____ have increased potency

Answer: lipids

Flashcard 39: Local anesthetics can also cause blockage of _____ and Ca2+ channels along with Na+ channel

Answer: K+

Flashcard 40: JENVAC (JEV strain _____) of JE vaccine is administered intramuscularly.

Answer: 82156-XY

Flashcard 41: The _____ dopamine receptor is coupled to Gi

Answer: D2

Flashcard 42: The _____ dopamine receptor is coupled to Gs

Answer: D1

Flashcard 43: Schedule _____ drugs include bacterial vaccines.

Answer: F

Flashcard 44: Which is the least toxic synthetic insecticide?_____

Answer: Abate

Flashcard 45: Vecuronium and rocuronium have _____ clearance

Answer: biliary

Flashcard 46: Which drug for COVID-19 acts by inhibiting ACE2 receptor interaction?_____

Answer: Umifenovir

Flashcard 47: Muscle relaxant having the maximum duration of action is _____

Answer: Doxacurium

Flashcard 48: _____ or delta 9 tetrahydrocannabinol is a cannabinoid that can be extracted naturally

Answer: Dronabinol

Flashcard 49: _____ is a drug which prevents the transportation of ADP into, and ATP out of, the mitochondria.

Answer: Atractyloside

Flashcard 50: Me-too drugs are chemically related to the prototype or other chemical compounds that have an identical _____

Answer: mechanism of action

Flashcard 51: The _____ formulation of etomidate is less frequently associated with pain on injection, thrombophlebitis, and histamine release

Answer: lipid

Flashcard 52: CXCR-4 antagonists such as Plerixafor work by blocking the binding of _____ to the CXCR-4

Answer: SDF1-alpha (ligand)

Flashcard 53: Schedule _____ drugs are marketed under generic name only

Answer: W

Flashcard 54: Which local anesthetic has the slowest onset of action?_____

Answer: Chloroprocaine

Flashcard 55: Schedule _____ drugs must be labeled with the word caution should not be taken without medical supervision

Answer: G

Flashcard 56: Commercially available local anaesthetic solutions have an acidic pH in order to maximize the stability, hence should be _____ before use

Answer: alkalinized

Flashcard 57: The therapeutic index of sevoflurane is _____ than halothane

Answer: higher

Flashcard 58: PCSK-9 inhibitors are administered as _____ injections.

Answer: subcutaneous

Flashcard 59: Schedule _____ drugs include biological and special products

Answer: C and C1

Flashcard 60: Schedule _____ drugs are psychotropic drugs requiring a special license for manufacture and sale

Answer: X

Flashcard 61: A pharmacologically inert substance used along with active ingredient in a formulation is called as an ____.

Answer: excipient

Flashcard 62: Which nerve fibres are the least susceptible to local anesthetics?_____

Answer: A gamma

Flashcard 63: _____ drugs are for the treatment or prevention of rare diseases with little commercial value for pharmaceutical companies.

Answer: Orphan

Flashcard 64: Muscle relaxant which crosses placenta is _____

Answer: Gallamine

Flashcard 65: Intensity of its inebriating effects of alcohol is directly proportional to its _____

Answer: molecular weight

Flashcard 66: Alkalinization of local anesthetics can lead to _____ pain on local injection

Answer: decreased

Flashcard 67: Which covid-19 vaccine consists of suspension of lipid particles which enable delivery of the RNA into host cells to allow expression of the spike (S) antigen?_____

Answer: Moderna and Pfizer

Flashcard 68: _____ is a buccal formulation of oxytocin that is similar to oxytocin injection

Answer: Desamino-oxytocin

Flashcard 69: The following is a flower of? _____

Answer: Calotropis gigantea

Flashcard 70: _____ is the S(-) enantiomer of bupivacaine

Answer: Ropivacaine

Flashcard 71: An eutectic mixture has a melting point _____ the individual drugs used for making it

Answer: below

Flashcard 72: After reconstitution, thiobarbiturates (eg. thiopentone) are stable if refrigerated for _____ week(s)

Answer: 1

Flashcard 73: All local anesthetics are vasodialators except _____

Answer: cocaine

Flashcard 74: Aspirin at _____ doses primarily acts by inhibiting cyclooxygenase 1 (COX-1).

Answer: low

Flashcard 75: After reconstitution, methohexital are stable if refrigerated for _____ week(s)

Answer: 6

Flashcard 76: Schedule _____ drugs should be sold only if the prescription is from a registered medical practitioner (RMP).

Answer: H

Flashcard 77: Thiopentone and other barbiturates are prepared as solutions with an _____ pH

Answer: alkaline

Flashcard 78: All H1 receptor antagonist act by _____ at the H1 receptor site

Answer: inverse agonism

Flashcard 79: DMPA-SC is given subcutaneously at a dose of _____ mg every 3 months

Answer: 104

Flashcard 80: Moxifloxacin is metabolized predominantly by the _____

Answer: liver

Flashcard 81: The potency of the injectable polio vaccine can be measured in terms of _____ units.

Answer: D antigen

Flashcard 82: _____ is monoclonal antibody which blocks type 1 inteferon

Answer: Anifrolumab

Flashcard 83: _____ plasma kallikrein inhibitor that can be given prophylactically in hereditary angioedema is _____.

Answer: Oral::Route; berotralstat

Flashcard 84: A _____ is a medication selected by a healthcare provider as the preferred choice for treating a specific condition

Answer: P-drug