Adverse Drug Reactions and Toxicity — Flashcards

Flashcard 1: Examples of drugs eliminated by zero-order elimination include _____, ethanol, and aspirin (high concentrations)

Answer: phenytoin

Flashcard 2: The inhaled anesthetic _____ is most commonly associated with hepatotoxicity as an adverse effect

Answer: halothane

Flashcard 3: Schedule _____ drugs include biological and special products

Answer: C and C1

Flashcard 4: Cytochrome p450 is a _____-oxygenase

Answer: mono (di/mono)

Flashcard 5: Dose chart for adrenaline and 1 mL ampoule of adrenaline (_____ aqueous solution)x3 are one of the components of the anaphylaxis kit

Answer: 1:1000 (ratio)

Flashcard 6: A pharmacologically inert substance used along with active ingredient in a formulation is called as an ____.

Answer: excipient

Flashcard 7: _____ is when bioavailability of active ingredient in 2 preparations of drug are not significantly different under identical conditions

Answer: Bioequivalence

Flashcard 8: _____ is a phenomenon that occurs when tolerance to the effects of one drug produces tolerance to another drug

Answer: Cross-tolerance

Flashcard 9: Freeze-sensitive vaccines include _____.

Answer: Hepatitis B, DPT, TT, Hib, PCV, and IPV

Extra: Freeze-sensitive vaccines (those containing aluminum adjuvants) lose potency if frozen. Examples include Hepatitis B, DPT, TT, Hib, PCV, and IPV. If freezing is suspected, the **Shake Test** is performed to determine if the vaccine is still usable. **Note:** Heat-sensitive vaccines (like OPV and Measles) are usually stored in the freezer compartment at the district level but are not "freeze-sensitive" in terms of damage; rather, they are "freeze-stable."

Flashcard 10: rubella vaccine(MMR) uses _____ strain

Answer: wistar RA27/3

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