Pediatric and Geriatric Pharmacology — Flashcards

Flashcard 1: Schedule _____ drugs are marketed under generic name only

Answer: W

Flashcard 2: Schedule _____ drugs include biological and special products

Answer: C and C1

Flashcard 3: When the rate of drug **administration** equals the rate of drug **elimination**, the drug has reached _____ concentration.

Answer: Steady-state concentration (Css)

Extra: Steady-state is achieved when the rate of drug administration (input) equals the rate of drug elimination (output). It typically takes 4–5 half-lives (t½) to reach steady-state. Formula for IV infusion: $Css = \frac{Rate\ of\ infusion}{Clearance}$

Flashcard 4: _____ drugs generally bind to alpha-1 acid glycoprotein in the blood

Answer: Basic

Flashcard 5: Loading dose is essential for chloroquine because of its property of _____

Answer: high Vd

Flashcard 6: Schedule _____ drugs include bacterial vaccines.

Answer: F

Flashcard 7: Which parameter is used to assess the extent of drug absorption in a plasma concentration vs. time graph?

Answer: Area under the curve (AUC)

Flashcard 8: _____ is when bioavailability of active ingredient in 2 preparations of drug are not significantly different under identical conditions

Answer: Bioequivalence

Flashcard 9: Freeze-sensitive vaccines include _____.

Answer: Hepatitis B, DPT, TT, Hib, PCV, and IPV

Extra: Freeze-sensitive vaccines (those containing aluminum adjuvants) lose potency if frozen. Examples include Hepatitis B, DPT, TT, Hib, PCV, and IPV. If freezing is suspected, the **Shake Test** is performed to determine if the vaccine is still usable. **Note:** Heat-sensitive vaccines (like OPV and Measles) are usually stored in the freezer compartment at the district level but are not "freeze-sensitive" in terms of damage; rather, they are "freeze-stable."

Flashcard 10: rubella vaccine(MMR) uses _____ strain

Answer: wistar RA27/3

Extra: