Drug-Receptor Interactions and Dose-Response — Flashcards

Flashcard 1: Schedule _____ drugs include biological and special products

Answer: C and C1

Flashcard 2: All H1 receptor antagonist act by _____ at the H1 receptor site

Answer: inverse agonism

Flashcard 3: _____ receptors bind glycoproteins and contain three domains; an extracellular domain for ligand binding, a transmembrane domain, and an intracellular domain coupled with heterotrimeric G proteins

Answer: G protein coupled

Flashcard 4: Which parameter is used to assess the extent of drug absorption in a plasma concentration vs. time graph?

Answer: Area under the curve (AUC)

Flashcard 5: The therapeutic index is calculated by _____/ED50

Answer: TD50

Flashcard 6: Time for peak plasma concentration (Tmax) of a drug indicates the rate of _____ from the administered site.

Answer: absorption

Flashcard 7: The loading dose of a drug is governed primarily by its _____

Answer: Vd

Flashcard 8: Freeze-sensitive vaccines include _____.

Answer: Hepatitis B, DPT, TT, Hib, PCV, and IPV

Extra: Freeze-sensitive vaccines (those containing aluminum adjuvants) lose potency if frozen. Examples include Hepatitis B, DPT, TT, Hib, PCV, and IPV. If freezing is suspected, the **Shake Test** is performed to determine if the vaccine is still usable. **Note:** Heat-sensitive vaccines (like OPV and Measles) are usually stored in the freezer compartment at the district level but are not "freeze-sensitive" in terms of damage; rather, they are "freeze-stable."

Flashcard 9: rubella vaccine(MMR) uses _____ strain

Answer: wistar RA27/3

Extra: 

Flashcard 10: Td vaccine contains _____ Lf units of diphtheria content

Answer: 2

Extra: Td (Tetanus and reduced-dose diphtheria) vaccine contains: - Tetanus Toxoid: 5 Lf - Diphtheria Toxoid: 2 Lf (The lowercase 'd' denotes reduced dose compared to 20-30 Lf in DPT/DT).