Pharmacodynamics and Receptor Theory — Flashcards

Flashcard 1: Me-too drugs are chemically related to the prototype or other chemical compounds that have an identical _____

Answer: mechanism of action

Flashcard 2: Schedule _____ drugs include bacterial vaccines.

Answer: F

Flashcard 3: Ligand gated ion channels are also known as _____ receptors

Answer: Ionotropic

Flashcard 4: The therapeutic index is calculated by _____/ED50

Answer: TD50

Flashcard 5: In the first step of the adenylyl cyclase and phospholipase C mechanism of signaling, binding of hormone to its receptor causes release of _____ from its subunit (s, i, or aq) and replacement by GTP

Answer: GDP

Flashcard 6: What is the shape of DRC for a ligand which downregulates its receptors?_____

Answer: Inverted-U shaped

Flashcard 7: Freeze-sensitive vaccines include _____.

Answer: Hepatitis B, DPT, TT, Hib, PCV, and IPV

Extra: Freeze-sensitive vaccines (those containing aluminum adjuvants) lose potency if frozen. Examples include Hepatitis B, DPT, TT, Hib, PCV, and IPV. If freezing is suspected, the **Shake Test** is performed to determine if the vaccine is still usable. **Note:** Heat-sensitive vaccines (like OPV and Measles) are usually stored in the freezer compartment at the district level but are not "freeze-sensitive" in terms of damage; rather, they are "freeze-stable."

Flashcard 8: rubella vaccine(MMR) uses _____ strain

Answer: wistar RA27/3

Extra: 

Flashcard 9: Td vaccine contains _____ Lf units of diphtheria content

Answer: 2

Extra: Td (Tetanus and reduced-dose diphtheria) vaccine contains: - Tetanus Toxoid: 5 Lf - Diphtheria Toxoid: 2 Lf (The lowercase 'd' denotes reduced dose compared to 20-30 Lf in DPT/DT).

Flashcard 10: _____ is protein based recombinant type vaccine for malaria

Answer: mosquirix

Extra: