Pharmacogenetics and Personalized Medicine — Flashcards

Flashcard 1: Schedule _____ drugs are marketed under generic name only

Answer: W

Flashcard 2: Which enzyme in the heme synthesis pathway is induced by barbiturates (and related drugs)?_____

Answer: $\delta$-aminolevulinic acid (ALA) synthase

Flashcard 3: Cytochrome p450 is a _____-oxygenase

Answer: mono (di/mono)

Flashcard 4: Sirolimus (rapamycin) is an immunosuppressant that blocks _____ cell activation via blocking a step in the IL-2 receptor signaling pathway

Answer: T

Flashcard 5: _____ is when bioavailability of active ingredient in 2 preparations of drug are not significantly different under identical conditions

Answer: Bioequivalence

Flashcard 6: Freeze-sensitive vaccines include _____.

Answer: Hepatitis B, DPT, TT, Hib, PCV, and IPV

Extra: Freeze-sensitive vaccines (those containing aluminum adjuvants) lose potency if frozen. Examples include Hepatitis B, DPT, TT, Hib, PCV, and IPV. If freezing is suspected, the **Shake Test** is performed to determine if the vaccine is still usable. **Note:** Heat-sensitive vaccines (like OPV and Measles) are usually stored in the freezer compartment at the district level but are not "freeze-sensitive" in terms of damage; rather, they are "freeze-stable."

Flashcard 7: rubella vaccine(MMR) uses _____ strain

Answer: wistar RA27/3

Extra: 

Flashcard 8: Td vaccine contains _____ Lf units of diphtheria content

Answer: 2

Extra: Td (Tetanus and reduced-dose diphtheria) vaccine contains: - Tetanus Toxoid: 5 Lf - Diphtheria Toxoid: 2 Lf (The lowercase 'd' denotes reduced dose compared to 20-30 Lf in DPT/DT).

Flashcard 9: _____ is protein based recombinant type vaccine for malaria

Answer: mosquirix

Extra: 

Flashcard 10: In IPV,lowest antibody production is with _____ serotype

Answer: P3

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