Anticancer Drugs — Flashcards

Flashcard 111: Which bispecific monoclonal antibody is useful for treating malignant ascites?

Answer: Catumaxomab

Flashcard 112: Nitrosoureas are _____ acting carcinogens.

Answer: directly

Flashcard 113: _____ is an irreversible aromatase inhibitor.

Answer: Exemestane

Flashcard 114: Methotrexate resistance is due to the overproduction of _____

Answer: DHFR.

Flashcard 115: What cell cycle phase is 5-FU (5-Fluorouracil) specific for?

Answer: S phase

Extra: 5-FU is a pyrimidine analog (antimetabolite) that inhibits thymidylate synthase, thereby inhibiting DNA synthesis. Like most antimetabolites, it is **S-phase specific**. Note: While some studies show concentration-dependent effects on other phases (like G2), for medical examinations (NEET PG, USMLE), 5-FU is the classic example of an S-phase specific drug.

Flashcard 116: Cerebellar toxicity is seen with which anti-cancer drug?_____

Answer: Cytarabine

Flashcard 117: Which drug is highly effective for relapsed or refractory acute promyelocytic leukemia?_____

Answer: Arsenic trioxide

Flashcard 118: _____-acting carcinogens require no metabolic conversion to become carcinogenic (incl. cancer chemorx drugs)

Answer: Direct

Flashcard 119: Sustained neutropenia is seen with _____

Answer: nitrosoureas (alkylating agent class)

Flashcard 120: Which anticancer agent is associated with secondary leukemia?_____

Answer: Cisplatin