Neoplasia — Flashcards

_____ is due to an inherited mutation in the APC gene on chromosome 5q

Progression of colonic adenoma to carcinoma occurs with mutations in the _____ or loss of heterozygosity in the region that encodes for SMAD 2 / 4

Most common malignant tumor of _____ salivary glands is Adenoid cystic carcinoma

Hint: minor/major

High malignant potential in GIST is determined by _____ cm size; >5 mitoses/50 HPF or _____ cm size; >5 mitoses/50 HPF

_____ is the malignant proliferation of cells in the ducts of the breast with no invasion of the basement membrane

The t(_____,14) translocation results in overexpression of c-myc, which promotes growth

_____ -sided colorectal carcinoma usually grows as a raised (exophytic) mass

Categories of proto-oncogenes include:_____2) Growth factor receptors3) Signal transducers4) Nuclear regulators5) Cell cycle regulators

Tumor cells can evade apoptosis / immune surveillance by downregulating expression of _____ or alternative splicing of the Fas receptor

Oral _____ and erythroplakia are precursor lesions to squamous cell carcinoma