Neoplasia — Flashcards

Embryonal carcinoma may have increased levels of _____ and normal or elevated levels of AFP

Tumor cells can evade apoptosis / immune surveillance by downregulating expression of _____ or alternative splicing of the Fas receptor

Categories of proto-oncogenes include:_____2) Growth factor receptors3) Signal transducers4) Nuclear regulators5) Cell cycle regulators

Oral _____ and erythroplakia are precursor lesions to squamous cell carcinoma

Bleeding may occur as a paraneoplastic syndrome in Wilm's tumor due to acquired deficiency of _____ factor or factor VII deficiency.

_____ is the malignant proliferation of cells in the ducts of the breast with no invasion of the basement membrane

Progression of colonic adenoma to carcinoma occurs with mutations in the _____ or loss of heterozygosity in the region that encodes for SMAD 2 / 4

High malignant potential in GIST is determined by _____ cm size; >5 mitoses/50 HPF or _____ cm size; >5 mitoses/50 HPF

The t(_____,14) translocation results in overexpression of c-myc, which promotes growth

Most common malignant tumor of _____ salivary glands is Adenoid cystic carcinoma

Hint: minor/major