Neoplasia — Flashcards

_____ is a non-invasive breast cancer characterized by dyscohesive cells due to lack of E-cadherin protein

One subtype of invasive ductal carcinoma (breast) is _____ carcinoma, which is characterized by large, high-grade malignant cells growing in sheets with lymphocytic infiltrate

Metastasis oncogenes such as _____ and TWIST encode transcription factors whose primary function is to promote epithelial-to-mesenchymal transition (EMT).

_____ tumor is metastatic mucinous tumor that involves both ovaries; most commonly due to metastatic gastric carcinoma (diffuse type)

_____ carcinoma of the lung may secrete the hormone -hCG

Birt-Hogg-Dube syndrome is due to _____ mutation and presents with multiple oncocytomas, chromophobe RCCs, facial fibrofolliculomas, lung cysts and spontaneous pneumothorax

Uncertain or low malignant potential in GIST is determined by _____ cm size; >5 mitoses/50 HPF

Gorlin syndrome is associated with a high risk of _____ carcinoma and medulloblastoma.

Chronic irritation of the bladder can cause _____ metaplasia, which may progress to squamous cell carcinoma

Small cell carcinoma is characterized histologically by _____ differentiated small cells and is thus very aggressive