Neoplasia — Flashcards

The tumor suppressors encoded by the CDKN2A gene enforce the G1-->S restriction point by:(1) - inhibiting CDK_____/6 (2) - relieving inhibition of P53

Prostatic adenocarcinoma often has _____ metastases, which is indicated by lower back pain

Hint: type

Acoustic neuromas are _____ whereas glomus tumors are encapsulated (capsulated/nah)

_____ disease is an inherited disease associated with increased risk for renal cell carcinoma and hemangioblastoma of the cerebellum

One subtype of invasive ductal carcinoma (breast) is _____ carcinoma, which is characterized by an erythematous and swollen breast that does not resolve with antibiotics

The KIT _____ encodes for the Stem Cell Factor receptor, which when bound leads to cell growthThis is a growth factor receptor found commonly in GI stromal tumor

Some _____ secrete PTH-related peptide (PTH-rp), which is structurally homologous with the PTH secreted by the parathyroid glands

Invasive lobular carcinoma grows in a _____ pattern due to lack of E-cadherin encoded by gene CDH-1

_____ lung carcinoma may produce the anterior pituitary hormone ACTH leading to Cushing syndrome

Patients with a germline Rb mutation will typically develop a _____ Retinoblastoma, with an increased risk of osteosarcoma and pinealoblastoma ("trilateral" retinoblastoma)