Hematopathology — Flashcards

Flashcard 391: Lymph node biopsy showing diffuse effacement with small lymphocytes and proliferation centers, is suggestive of _____

Answer: chronic lymphocytic leukemia/small lymphocytic lymphoma

Flashcard 392: Which non-hodgkin's lymphoma presents most commonly as a destructive nasopharyngeal mass?_____

Answer: Extranodal NK/T-Cell Lymphoma

Flashcard 393: Marrow biopsy of patients with _____ leukemia may show macrophages engulfing the apoptotic tumor cells, giving it a "starry sky" appearance.

Answer: Burkitt leukemia (Acute Lymphoblastic Leukemia, FAB L3 subtype)

Flashcard 394: What AML subtype is associated with CD41/61?_____

Answer: AML M7 (megakaryocytic)

Flashcard 395: Which cellular markers are absent from early pre-B acute leukemias?_____

Answer: CD10, CD20 and Cy Ig

Flashcard 396: What is the least common type of AML?_____

Answer: AML M7

Flashcard 397: Hemophagocytic lymphohistiocytosis is characterized by elevated levels of CD_____

Answer: 25

Flashcard 398: Monocytoid B cells in sinuses are seen in _____ stages of HIV infection

Answer: early

Flashcard 399: Lysozymes and alkaline phosphatase are a part of _____ granules of neutrophils.

Answer: secondary (specific)

Flashcard 400: Hemoglobin level associated with poor prognosis in Hodgkin Lymphoma (International Prognostic Score criteria)

Answer: < 10.5 g/dL

Extra: The International Prognostic Score (IPS) for Advanced Hodgkin Lymphoma (Hasenclever index) includes 7 factors: 1. Albumin < 4 g/dL 2. **Hemoglobin < 10.5 g/dL** 3. Male sex 4. Age ≥ 45 years 5. Stage IV disease 6. Leukocytosis (WBC ≥ 15,000/mm³) 7. Lymphocytopenia (< 600/mm³ or < 8% of differential)