Hematopathology — Flashcards

Flashcard 391: Lymph node biopsy showing diffuse effacement with small lymphocytes and proliferation centers, is suggestive of _____

Answer: chronic lymphocytic leukemia/small lymphocytic lymphoma

Flashcard 392: The most common site of extra-nodal lymphoma is the _____

Answer: stomach

Flashcard 393: Which cellular markers are absent from early pre-B acute leukemias?_____

Answer: CD10, CD20 and Cy Ig

Flashcard 394: Which variant of large-cell non-Hodgkin lymphomas is associated with Reed-Sternberg cells?_____

Answer: immunoblastic NHL

Flashcard 395: Lysozymes and alkaline phosphatase are a part of _____ granules of neutrophils.

Answer: secondary (specific)

Flashcard 396: The estimation of prothrombin time (PT) and activated Partial Thromboplastin Time (aPTT) requires platelet-_____ plasma

Answer: poor

Flashcard 397: Hemoglobin level associated with poor prognosis in Hodgkin Lymphoma (International Prognostic Score criteria)

Answer: < 10.5 g/dL

Extra: The International Prognostic Score (IPS) for Advanced Hodgkin Lymphoma (Hasenclever index) includes 7 factors: 1. Albumin < 4 g/dL 2. **Hemoglobin < 10.5 g/dL** 3. Male sex 4. Age ≥ 45 years 5. Stage IV disease 6. Leukocytosis (WBC ≥ 15,000/mm³) 7. Lymphocytopenia (< 600/mm³ or < 8% of differential)

Flashcard 398: Lowest number of Reed-Sternberg cells is seen in the _____ variant of Hodgkin lymphoma

Answer: Lymphocyte predominant

Flashcard 399: What is the least common type of AML?_____

Answer: AML M7

Flashcard 400: For testing PTT, the sample is activated by using _____

Answer: kaolin/silica/ellagic acid