Hematopathology — Flashcards

Flashcard 371: What name is given to the plasma cells seen in myeloma (typically IgA) that contain immunoglobulin within dilated cisternae of the endoplasmic reticulum?

Answer: Thesaurocytes

Extra: Thesaurocytes are a morphological variant of plasma cells, typically associated with IgA myeloma. They are characterized by the accumulation of immunoglobulin within dilated cisternae of the rough endoplasmic reticulum (RER), giving the cell a 'storage cell' appearance.

Flashcard 372: Hereditary _____ is a type of hemolytic anemia causing extreme variation in RBC size and shape.

Answer: pyropoikilocytosis

Flashcard 373: Which B-cell associated antigens are expressed with Burkitt's lymphoma (non-EBV)?_____

Answer: CD19, CD20, CD22, CD79a (4)

Flashcard 374: Which immunoglobulin type of multiple myeloma is characteristically associated with a very small or absent M spike on serum electrophoresis?

Answer: IgD

Flashcard 375: Rearrangements in the _____ gene is seen in anaplastic large cell lymphoma

Answer: ALK

Flashcard 376: EBV-positive diffuse large B-cell lymphoma (DLBCL), NOS is typically seen in elderly patients (> 50 years) __________ (with/without) known prior immunodeficiency or lymphoma.

Answer: Without

Flashcard 377: _____ bodies are siderotic nodules in spleen seen in cases of congestive splenomegaly and sickle cell disease

Answer: Gamna-Gandy

Flashcard 378: The size of -BCR ABL (micro BCR) protein in t(9;22) associated with myeloproliferative neoplasm (MPN) is _____ kDa.

Answer: 230

Flashcard 379: Which classes of AML show strong positivity for non-specific esterases?_____

Answer: M4, M5

Flashcard 380: Which cell organelles fuse to form **Auer rods** in AML?

Answer: Lysosomes (Primary azurophilic granules)