Hematopathology — Flashcards

Flashcard 361: What AML subtype is associated with eosinophilia?_____

Answer: AML M4eo (myelomonocytic with eosinophilia)

Flashcard 362: t(14;16), del 17p, and t(4;14) in multiple myeloma is associated with a _____ prognosis

Answer: poor

Flashcard 363: The most common cytogenetic change in multiple myeloma is the deletion of _____

Answer: 13q (or Monosomy 13)

Extra: Deletion of 13q is the most common structural cytogenetic abnormality in Multiple Myeloma, seen in approximately 50% of cases. While translocations involving **14q32** (the IgH locus) are also very common, the most common *deletion* is 13q.

Flashcard 364: In touch preparations of Extranodal NK/T-Cell Lymphoma, large _____philic granules are seen in the cytoplasm of the tumor cells

Answer: azuro

Flashcard 365: Which variant of Reed-Sternberg cells is seen with lymphocyte depleted subtype of Hodgkin's lymphoma?_____

Answer: reticular variant

Flashcard 366: What name is given to the plasma cells seen in myeloma (typically IgA) that contain immunoglobulin within dilated cisternae of the endoplasmic reticulum?

Answer: Thesaurocytes

Extra: Thesaurocytes are a morphological variant of plasma cells, typically associated with IgA myeloma. They are characterized by the accumulation of immunoglobulin within dilated cisternae of the rough endoplasmic reticulum (RER), giving the cell a 'storage cell' appearance.

Flashcard 367: _____ is the most specific marker of Reed Sternberg cell

Answer: PAX5

Flashcard 368: _____ lymphadenitis is also known as histiocytic necrotizing lymphadenitis.

Answer: Kikuchi's

Flashcard 369: Hereditary _____ is a type of hemolytic anemia causing extreme variation in RBC size and shape.

Answer: pyropoikilocytosis

Flashcard 370: Blasts usually make up _____% of the circulating cells in accelerated phase of chronic myeloid leukemia

Answer: 10-19